Drug.Combination PMID Function Species Effect Target Regulation Journal Cell.Type Cell.Name Detection.Method (-)-Epicatechin 28768059 Heart-toxicity Homo sapiens detoxicity SP1 Downregulation J Biochem Mol Toxicol Embryonic kidney cell HEK-293 Western blot (-)-Epigallocatechin-3-gallate 16115949 Bone-toxicity Homo sapiens synergy - - Clin Cancer Res - - - (-)-Epigallocatechin-3-gallate 16115949 Myeloma Homo sapiens synergy - - Clin Cancer Res Myeloma cell RPMI 8226 - (-)-Epigallocatechin-3-gallate 16115949 Myeloma Homo sapiens synergy - - Clin Cancer Res Myeloma cell U266 - (-)-Epigallocatechin-3-gallate 16115949 Lymphoma Homo sapiens synergy BCL2 Upregulation Clin Cancer Res Burkitt's lymphoma cell HS-Sultan Western blot (-)-Epigallocatechin-3-gallate 16115949 Lymphoma Homo sapiens synergy CASP3 Upregulation Clin Cancer Res Burkitt's lymphoma cell HS-Sultan Western blot (-)-Epigallocatechin-3-gallate 16115949 Myeloma Homo sapiens synergy GSH Downregulation Clin Cancer Res Multiple myeloma cell IM-9 Flow cytometry (-)-Epigallocatechin-3-gallate 16115949 Lymphoma Homo sapiens synergy MCL1 Upregulation Clin Cancer Res Burkitt's lymphoma cell HS-Sultan Western blot (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy - - Cancers (Basel) Glioma stem cell GS-5 - (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy BIRC5 Downregulation Cancers (Basel) Glioma stem cell GS-5 QRT-PCR,Western blot (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy CHK1 Phosphorylation,Downregulation Cancers (Basel) Glioma stem cell GS-5 QRT-PCR,Western blot (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy CHK2 Downregulation Cancers (Basel) Glioma stem cell GS-5 QRT-PCR,Western blot (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy OLIG2 Downregulation Cancers (Basel) Glioma stem cell GS-5 QRT-PCR,Western blot (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy RAD51 Downregulation Cancers (Basel) Glioma stem cell GS-5 QRT-PCR (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy SOX2 Downregulation Cancers (Basel) Glioma stem cell GS-5 QRT-PCR,Western blot, IFA (-)-Gossypol 30871073 Brain-cancer Homo sapiens synergy SOX9 Downregulation Cancers (Basel) Glioma stem cell GS-5 QRT-PCR,Western blot (+)Alpha-tocopheryl-succinate 19013639 Leukemia Homo sapiens synergy - - Leuk Res - - - (+)Alpha-tocopheryl-succinate 19013639 Leukemia Homo sapiens synergy - - Leuk Res Acute promyelocytic leukemia cell NB4 - 10058-f4 30639430 Leukemia Homo sapiens synergy - - Int J Biochem Cell Biol Acute lymphoblastic leukemia cell NALM6 - 10058-f4 30639430 Leukemia Homo sapiens synergy - - Int J Biochem Cell Biol Acute promyelocytic leukemia cell NB4 - 10058-f4 26038891 Brain-cancer Homo sapiens synergy - - PLoS One Cancer stem-like cell RI01 - 10058-f4 26038891 Brain-cancer Homo sapiens synergy - - PLoS One Cancer stem-like cell RI02 - 10058-f4 26038891 Brain-cancer Homo sapiens synergy - - PLoS One Cancer stem-like cell RI03 - 10058-f4 26038891 Brain-cancer Homo sapiens synergy - - PLoS One Cancer stem-like cell RI08 - 12-o-tetradecanoylphorbol-13-acetate 14610070 Leukemia Homo sapiens synergy - - J Biol Chem Acute promyelocytic leukemia cell HL-60 - 12-o-tetradecanoylphorbol-13-acetate 25130808 Leukemia Homo sapiens synergy ITGAM Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 Flow cytometry 12-o-tetradecanoylphorbol-13-acetate 14610070 Leukemia Homo sapiens synergy JNK Phosphorylation J Biol Chem Histiocytic lymphoma cell U-937 Western blot 12-o-tetradecanoylphorbol-13-acetate 14610070 Leukemia Homo sapiens synergy P38 MAPK Phosphorylation J Biol Chem Histiocytic lymphoma cell U-937 Western blot 12-o-tetradecanoylphorbol-13-acetate 25130808 Leukemia Homo sapiens synergy P38 MAPK Phosphorylation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 Western blot 17-AAG 16482209 Leukemia Homo sapiens synergy - - Leukemia Leukemia cell Jurkat - 17-AAG 16482209 Leukemia Homo sapiens synergy - - Leukemia Leukemia cell Primary leukemia cell - 17-AAG 16482209 Leukemia Homo sapiens synergy - - Leukemia Leukemia cell Primary leukemia cell - 17-AAG 16482209 Leukemia Homo sapiens synergy AKT1 Phosphorylation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot 17-DMAG 19371599 Cervical-cancer Homo sapiens synergy BUBR1 Upregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot 17-DMAG 19371599 Cervical-cancer Homo sapiens synergy CASP9 Downregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot 17-DMAG 19371599 Cervical-cancer Homo sapiens synergy PARP1 Upregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Flow cytometry, Western blot 17-DMAG 19371599 Cervical-cancer Homo sapiens synergy PDS1 Upregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy - - Cancer Res Acute promyelocytic leukemia cell HL-60 - 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy - - Cancer Res Acute promyelocytic leukemia cell NB4 - 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy - - Cancer Res Histiocytic lymphoma cell U-937 - 19-nor-1,25(oh)-2-d-2 15781666 Myeloma Homo sapiens synergy - - Cancer Res Myeloma cell RPMI 8226 - 19-nor-1,25(oh)-2-d-2 15781666 Myeloma Homo sapiens synergy - - Cancer Res Leukemia cell ARH-77 - 19-nor-1,25(oh)-2-d-2 15781666 Myeloma Homo sapiens synergy - - Cancer Res Myeloma cell NCI-H929 - 19-nor-1,25(oh)-2-d-2 15781666 Lung-cancer Homo sapiens synergy - - Cancer Res Lung cancer cell NCI-H125 - 19-nor-1,25(oh)-2-d-2 15781666 Lung-cancer Homo sapiens synergy - - Cancer Res Lung cancer cell NCI-H520 - 19-nor-1,25(oh)-2-d-2 15781666 Prostate-cancer Homo sapiens synergy - - Cancer Res Prostate carcinoma cell LNCaP - 19-nor-1,25(oh)-2-d-2 15781666 Prostate-cancer Homo sapiens synergy - - Cancer Res Prostate carcinoma cell PC-3 - 19-nor-1,25(oh)-2-d-2 15781666 Breast-cancer Homo sapiens synergy - - Cancer Res Breast cancer cell MCF7 - 19-nor-1,25(oh)-2-d-2 15781666 Breast-cancer Homo sapiens synergy - - Cancer Res Breast cancer cell MDA-MB-231 - 19-nor-1,25(oh)-2-d-2 15781666 Colorectal-cancer Homo sapiens synergy - - Cancer Res Colorectal adenocarcinoma cell HT-29 - 19-nor-1,25(oh)-2-d-2 15781666 Prostate-cancer Homo sapiens synergy - - Cancer Res Prostate carcinoma cell DU 145 - 19-nor-1,25(oh)-2-d-2 15781666 Endometrial-cancer Homo sapiens synergy - - Cancer Res Endometrial cancer cell Ishikawa - 19-nor-1,25(oh)-2-d-2 15781666 Endometrial-cancer Homo sapiens synergy - - Cancer Res Endometrial cancer cell HEC59 - 19-nor-1,25(oh)-2-d-2 15781666 Endometrial-cancer Homo sapiens synergy - - Cancer Res Endometrium adenocarcinoma cell HEC-1-B - 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy BAX Upregulation Cancer Res Acute promyelocytic leukemia cell HL-60 Western blot 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy BCL2 Downregulation Cancer Res Acute promyelocytic leukemia cell HL-60 Western blot 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy BCL2L1 Downregulation Cancer Res Acute promyelocytic leukemia cell HL-60 Western blot 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy CD14 Upregulation Cancer Res Acute promyelocytic leukemia cell NB4 Flow cytometry 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy CEBPB Upregulation Cancer Res Acute promyelocytic leukemia cell HL-60 Western blot 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy ERK1 Phosphorylation Cancer Res Acute promyelocytic leukemia cell HL-60 Western blot 19-nor-1,25(oh)-2-d-2 15781666 Leukemia Homo sapiens synergy PRAM1 Downregulation Cancer Res Acute promyelocytic leukemia cell NB4 Western blot 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy - - Biochem Pharmacol Acute promyelocytic leukemia cell HL-60 - 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy - - Biochem Pharmacol Histiocytic lymphoma cell U-937 - 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy - - Biochem Pharmacol Acute promyelocytic leukemia cell NB4 - 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy - - Biochem Pharmacol Acute monocytic leukemia cell THP-1 - 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy CASP3 Downregulation Biochem Pharmacol Acute promyelocytic leukemia cell HL-60 Western blot 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy CASP9 Downregulation Biochem Pharmacol Acute promyelocytic leukemia cell HL-60 Western blot 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy LKB1 Downregulation Biochem Pharmacol Acute promyelocytic leukemia cell HL-60 Western blot 2-deoxy-d-glucose 23041229 Leukemia Homo sapiens synergy PRKAA1 Downregulation Biochem Pharmacol Acute promyelocytic leukemia cell HL-60 Western blot 2-mercaptoethanol,2-ME 31905813 Bone-cancer Homo sapiens synergy - - Cells - - - 2-mercaptoethanol,2-ME 31905813 Bone-cancer Homo sapiens synergy - - Cells - - - 2-mercaptoethanol,2-ME 31905813 Bone-cancer Homo sapiens synergy - - Cells - - - 2-mercaptoethanol,2-ME 31905813 Bone-cancer Homo sapiens synergy - - Cells - - - 2-mercaptoethanol,2-ME 31905813 Bone-cancer Homo sapiens synergy - - Cells Osteosarcoma cell MG-63 - 2-mercaptoethanol,2-ME 31905813 Bone-cancer Homo sapiens synergy - - Cells Osteosarcoma cell U-2 OS - 2-methoxyestradiol 12531810 Leukemia Homo sapiens synergy - - Blood Leukemia cell Primary leukemia cell - 2-methoxyestradiol 23967052 Bladder-cancer Homo sapiens synergy - - PLoS One Urothelial cell SV-HUC - 2-methoxyestradiol 23967052 Bladder-cancer Homo sapiens synergy - - PLoS One Bladder transitional carcinoma cell NTUB1 - 2-methoxyestradiol 23967052 Bladder-cancer Homo sapiens synergy - - PLoS One Bladder carcinoma cell T24 - 2-methoxyestradiol 23967052 Bladder-cancer Homo sapiens synergy CASP3 Upregulation PLoS One Bladder transitional carcinoma cell NTUB1 Western blot 2-methoxyestradiol 23967052 Bladder-cancer Homo sapiens synergy CASP3 Upregulation PLoS One Bladder carcinoma cell T24 Western blot 2-methoxyestradiol 23967052 Bladder-cancer Homo sapiens synergy CASP7 Upregulation PLoS One Bladder transitional carcinoma cell NTUB1 Western blot 2-methoxyestradiol 23967052 Bladder-cancer Homo sapiens synergy CASP7 Upregulation PLoS One Bladder carcinoma cell T24 Western blot 2,3-bis(acetylthio)propanesulfonamide 1608923 Liver-toxicity Cavia porcellus detoxicity - - Pharmacol Toxicol - - - 2,3-bis(acetylthio)propanesulfonamide 1647157 Liver-toxicity Cavia porcellus detoxicity - - Arch Toxicol - - - 3'-azido-3'-deoxythymidine 21502917 Liver-cancer Homo sapiens synergy - - Anticancer Drugs Hepatocellular carcinoma cell HEPG2 - 3'-azido-3'-deoxythymidine 21502917 Liver-cancer Homo sapiens synergy - - Anticancer Drugs Hepatocellular carcinoma cell SMMC-7721 - 3'-azido-3'-deoxythymidine 21502917 Liver-cancer Mus musculus synergy - - Anticancer Drugs Liver cancer cell H22 - 3'-azido-3'-deoxythymidine 29910624 Liver-cancer Homo sapiens synergy - - Onco Targets Ther Hepatocellular carcinoma cell HEPG2 - 3-MA 32044640 Reproductive-toxicity Mus musculus detoxicity Atg7 Upregulation J Hazard Mater Testis leydig tumor cell MLTC-1 Western blot 3-MA 33352257 Liver-toxicity Mus musculus detoxicity Casp3 Upregulation In Vitro Normal hepatocyte AML12 QRT-PCR, Western blot 3-MA 33352257 Liver-toxicity Mus musculus detoxicity Map1lc3a Upregulation In Vitro Normal hepatocyte AML12 QRT-PCR, Western blot 3-MA 32044640 Reproductive-toxicity Mus musculus detoxicity Map1lc3a Upregulation J Hazard Mater Testis leydig tumor cell MLTC-1 Western blot 3-MA 33352257 Liver-toxicity Mus musculus detoxicity P62 Upregulation In Vitro Normal hepatocyte AML12 QRT-PCR, Western blot 3-MA 32044640 Reproductive-toxicity Mus musculus detoxicity P62 Upregulation J Hazard Mater Testis leydig tumor cell MLTC-1 Western blot 3-methyladenine 20107931 Leukemia Homo sapiens synergy - - Med Oncol Acute promyelocytic leukemia cell NB4 - 4-amino-1,8-naphthalimide 25924422 Liver-cancer Homo sapiens synergy - - Sichuan Da Xue Xue Bao Yi Xue Ban Hepatocellular carcinoma cell HEPG2 - 4-amino-1,8-naphthalimide 25499136 Liver-cancer Homo sapiens synergy - - Chem Biol Interact Hepatocellular carcinoma cell HEPG2 - 4-amino-1,8-naphthalimide 25499136 Liver-cancer Homo sapiens synergy CASP3 Upregulation Chem Biol Interact Hepatocellular carcinoma cell HEPG2 Western blot 4-amino-1,8-naphthalimide 25499136 Liver-cancer Homo sapiens synergy CCNB1 Downregulation Chem Biol Interact Hepatocellular carcinoma cell HEPG2 QRT-PCR, Western blot 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Atf4 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Chop Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Eif2a Phosphorylation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 Western blot 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Erk1 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Grp78 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Grp94 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Hrd1 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR 4-phenylbutyric-acid 23954561 Immune-toxicity Mus musculus detoxicity Xbp1 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR 5-aminolevulinic-acid 23962849 Brain-cancer Rattus norvegicus synergy - - J Photochem Photobiol B Cortical astrocyte Rat cortical astrocyte - 5-aminolevulinic-acid 23962849 Brain-cancer Homo sapiens synergy CPOX Upregulation J Photochem Photobiol B Glioblastoma cell U-87 MG QRT-PCR 5-aminolevulinic-acid 23962849 Brain-cancer Homo sapiens synergy CPOX Upregulation J Photochem Photobiol B Glioma cell T98MG QRT-PCR 5-aminolevulinic-acid 23962849 Brain-cancer Homo sapiens synergy PPIX Upregulation J Photochem Photobiol B Glioblastoma cell U-87 MG QRT-PCR,Flow cytometry 5-aminolevulinic-acid 23962849 Brain-cancer Homo sapiens synergy PPIX Upregulation J Photochem Photobiol B Glioma cell T98MG QRT-PCR,Flow cytometry 5-aza-2'-deoxycytidine 20038232 Leukemia Homo sapiens synergy - - Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 - 5-aza-2'-deoxycytidine 24762999 Leukemia Homo sapiens synergy JAK3 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 QRT-PCR 5-aza-2'-deoxycytidine 24762999 Leukemia Homo sapiens synergy SHP1 Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 QRT-PCR 5-aza-2'-deoxycytidine 24762999 Leukemia Homo sapiens synergy TYK2 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 QRT-PCR 5-azacytidine 19549372 Myeloma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell XG-7 - 5-fluorouracil 26692822 Liver-cancer Homo sapiens synergy HIF1A Downregulation Cancer Cell Int Hepatocellular carcinoma cell HEPG2 Western blot 5-fluorouracil 26692822 Liver-cancer Homo sapiens synergy LRP Downregulation Cancer Cell Int Hepatocellular carcinoma cell HEPG2 QRT-PCR, Western blot 5-fluorouracil 26692822 Liver-cancer Homo sapiens synergy MRP1 Downregulation Cancer Cell Int Hepatocellular carcinoma cell HEPG2 QRT-PCR, Western blot 5-fluorouracil 26692822 Liver-cancer Homo sapiens synergy PGP Downregulation Cancer Cell Int Hepatocellular carcinoma cell HEPG2 QRT-PCR, Western blot 8-cpt-camp 11807007 Leukemia Homo sapiens synergy - - Blood Acute promyelocytic leukemia cell NB4 - 8-cpt-camp 12679001 Leukemia Homo sapiens synergy E2F Upregulation Zhonghua Xue Ye Xue Za Zhi Acute promyelocytic leukemia cell NB4 Western blot 8-cpt-camp 12679001 Leukemia Homo sapiens synergy P21 Upregulation Zhonghua Xue Ye Xue Za Zhi Acute promyelocytic leukemia cell NB4 Western blot 89-strontium-chloride 22922982 Breast-cancer Homo sapiens synergy BCL2 Downregulation Oncol Rep Breast cancer cell MCF7 RT-PCR, Western blot 9-cis-retinoic-acid 11775865 Leukemia Homo sapiens synergy - - Chin Med J (Engl) Acute promyelocytic leukemia cell HL-60 - 9-phenanthrol 31054354 Vascular-toxicity Homo sapiens detoxicity TRPM4 Upregulation Toxicol Lett Human umbilical vein endothelial cells HUVECs QRT-PCR,Western blot, IFA ABT-737 31906234 Cervical-cancer Homo sapiens synergy - - Cancers (Basel) Cervical carcinoma cell Ca Ski - ABT-737 31906234 Cervical-cancer Homo sapiens synergy - - Cancers (Basel) Cervix squamous cell carcinoma cell SiHa - ABT-737 22971477 Gastric-cancer Homo sapiens synergy - - J Int Med Res Gastric adenocarcinoma cell SGC-7901 - ABT-737 22971477 Gastric-cancer Homo sapiens synergy - - J Int Med Res Gastric cancer cell MGC-803 - ABT-737 31906234 Cervical-cancer Homo sapiens synergy ADENINE Upregulation Cancers (Basel) Cervical carcinoma cell Ca Ski Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy ADENINE Upregulation Cancers (Basel) Cervix squamous cell carcinoma cell SiHa Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy CASP3 Upregulation J Int Med Res Gastric adenocarcinoma cell SGC-7901 Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy CASP3 Upregulation J Int Med Res Gastric cancer cell MGC-803 Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy CASP9 Upregulation J Int Med Res Gastric adenocarcinoma cell SGC-7901 Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy CASP9 Upregulation J Int Med Res Gastric cancer cell MGC-803 Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy CDK6 Downregulation Cancers (Basel) Cervical carcinoma cell Ca Ski Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy CDK6 Downregulation Cancers (Basel) Cervix squamous cell carcinoma cell SiHa Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy MAP1LC3A Upregulation Cancers (Basel) Cervical carcinoma cell Ca Ski Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy MAP1LC3A Upregulation Cancers (Basel) Cervix squamous cell carcinoma cell SiHa Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy MCL1 Upregulation Cancers (Basel) Cervical carcinoma cell Ca Ski Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy MCL1 Upregulation Cancers (Basel) Cervix squamous cell carcinoma cell SiHa Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy MCL1 Downregulation J Int Med Res Gastric adenocarcinoma cell SGC-7901 Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy MCL1 Upregulation J Int Med Res Gastric adenocarcinoma cell SGC-7901 Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy MCL1 Downregulation J Int Med Res Gastric cancer cell MGC-803 Western blot ABT-737 22971477 Gastric-cancer Homo sapiens synergy MCL1 Upregulation J Int Med Res Gastric cancer cell MGC-803 Western blot ABT-737 31906234 Cervical-cancer Homo sapiens synergy TYMS Downregulation Cancers (Basel) Cervix squamous cell carcinoma cell SiHa Western blot AC-73 30467201 Leukemia Homo sapiens synergy ERK1 Phosphorylation,Downregulation Haematologica Histiocytic lymphoma cell U-937 Western blot AC-73 30467201 Leukemia Homo sapiens synergy ERK1 Phosphorylation,Downregulation Haematologica Acute promyelocytic leukemia cell NB4 Western blot AC-73 30467201 Leukemia Homo sapiens synergy ERK1 Phosphorylation,Downregulation Haematologica Biphenotypic B myelomonocytic leukemia cell MV-4-11 Western blot AC-73 30467201 Leukemia Homo sapiens synergy STAT3 Phosphorylation,Downregulation Haematologica Histiocytic lymphoma cell U-937 Western blot AC-73 30467201 Leukemia Homo sapiens synergy STAT3 Phosphorylation,Downregulation Haematologica Acute promyelocytic leukemia cell NB4 Western blot AC-73 30467201 Leukemia Homo sapiens synergy STAT3 Phosphorylation,Downregulation Haematologica Biphenotypic B myelomonocytic leukemia cell MV-4-11 Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy - - Leuk Lymphoma Acute myelogenous leukemia cell KG-1a - Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy BCL2 Downregulation Leuk Lymphoma Acute myelogenous leukemia cell KG-1a Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy BCL2 Downregulation Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy CASP3 Upregulation Leuk Lymphoma Acute myelogenous leukemia cell KG-1a Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy CASP3 Upregulation Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy DIABLO Upregulation Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy IAP Downregulation Leuk Lymphoma Acute myelogenous leukemia cell KG-1a Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy IAP Downregulation Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy XIAP Downregulation Leuk Lymphoma Acute myelogenous leukemia cell KG-1a Western blot Aclacinomycin-a 25739941 Leukemia Homo sapiens synergy XIAP Upregulation Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 Western blot Adaphostin 19720055 Leukemia Homo sapiens synergy - - Chem Biol Interact Histiocytic lymphoma cell U-937 - Adaphostin 19720055 Leukemia Homo sapiens synergy P38 MAPK Upregulation,Phosphorylation Chem Biol Interact Histiocytic lymphoma cell U-937 Western blot Adriamycin 26524030 Lymphoma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Burkitt's lymphoma cell Raji - Adriamycin 26524030 Lymphoma Homo sapiens synergy BAX Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Burkitt's lymphoma cell Raji Western blot Adriamycin 26524030 Lymphoma Homo sapiens synergy BCL2 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Burkitt's lymphoma cell Raji Western blot Adriamycin 26524030 Lymphoma Homo sapiens synergy CASP3 Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Burkitt's lymphoma cell Raji Western blot Adriamycin 26524030 Lymphoma Homo sapiens synergy NFKB Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Burkitt's lymphoma cell Raji Western blot Adriamycin 19587434 Lymphoma Homo sapiens - P53 Downregulation Zhong Nan Da Xue Xue Bao Yi Xue Ban Burkitt's lymphoma cell Raji RT-PCR Adriamycin 26524030 Lymphoma Homo sapiens synergy P53 Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Burkitt's lymphoma cell Raji Western blot Adriamycin 26524030 Lymphoma Homo sapiens synergy SURVIVIN Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Burkitt's lymphoma cell Raji Western blot Allicin 27561292 Liver-toxicity Rattus norvegicus detoxicity Bax Upregulation Biol Trace Elem Res - - Western blot Allicin 27561292 Liver-toxicity Rattus norvegicus detoxicity Bclxll Downregulation Biol Trace Elem Res - - Western blot Allicin 27561292 Liver-toxicity Rattus norvegicus detoxicity HO1 Downregulation Biol Trace Elem Res - - Western blot Allicin 27561292 Liver-toxicity Rattus norvegicus detoxicity Klf9 Downregulation Biol Trace Elem Res - - Western blot Allicin 27561292 Liver-toxicity Rattus norvegicus detoxicity Nfkb Upregulation Biol Trace Elem Res - - Western blot Allicin 27561292 Liver-toxicity Rattus norvegicus detoxicity Nqo1 Downregulation Biol Trace Elem Res - - Western blot Allicin 27561292 Liver-toxicity Rattus norvegicus detoxicity NRF2 Downregulation Biol Trace Elem Res - - Western blot Alpha-inter-feron 15273095 HCV-infection Homo sapiens synergy - - Antimicrob Agents Chemother Liver cancer cell Huh7 - Alpha-inter-feron 15273095 HCV-infection Homo sapiens synergy NS3 Downregulation Antimicrob Agents Chemother Liver cancer cell Huh7 Western blot Alpha-lipoic acid 28533572 Hematologic-toxicity Rattus norvegicus detoxicity - - Iran J Med Sci - - - Alpha-lipoic acid 17258074 Leukemia Homo sapiens detoxicity - - Exp Hematol Acute promyelocytic leukemia cell NB4 - Alpha-lipoic acid 17258074 Leukemia Homo sapiens detoxicity - - Exp Hematol Acute promyelocytic leukemia cell HL-60 - Alpha-lipoic acid 17258074 Myeloma Homo sapiens detoxicity - - Exp Hematol Myeloma cell U266 - Alpha-lipoic acid 17258074 Myeloma Homo sapiens detoxicity - - Exp Hematol Multiple myeloma cell KMS12BM - Alpha-lipoic acid 23474023 Heart-toxicity Cavia porcellus detoxicity - - Eur J Pharmacol - - - Alpha-lipoic acid 17258074 Kidney-toxicity Homo sapiens detoxicity HMOX1 Upregulation Exp Hematol Embryonic renal cell PRCC QRT-PCR Alpha-lipoic acid 17258074 Kidney-toxicity Homo sapiens detoxicity HMOX1 Upregulation Exp Hematol Embryonic kidney cell HEK-293 QRT-PCR Alpha-lipoic acid 17258074 Kidney-toxicity Homo sapiens detoxicity HO1 Upregulation Exp Hematol Embryonic renal cell PRCC Western blot Alpha-lipoic acid 17258074 Kidney-toxicity Homo sapiens detoxicity HO1 Upregulation Exp Hematol Embryonic kidney cell HEK-293 Western blot Alpha-tocopherol 23950573 Reproductive-toxicity Rattus norvegicus detoxicity - - J Basic Clin Physiol Pharmacol - - - Alpha-tocopherol 29297235 Heart-toxicity Rattus norvegicus detoxicity Bcl2 Downregulation Toxicol Mech Methods Heart myoblast H9C2 RT-PCR Alpha-tocopherol 32154163 Leukemia Homo sapiens synergy BCL2 Downregulation Front Oncol Acute promyelocytic leukemia cell HL-60 RT-PCR Alpha-tocopherol 29697268 Liver-toxicity Homo sapiens detoxicity BCL2 Downregulation Nutr Cancer Liver cell Chang liver cell RT-PCR Alpha-tocopherol 29297235 Heart-toxicity Rattus norvegicus detoxicity Nrf2 Downregulation Toxicol Mech Methods Heart myoblast H9C2 RT-PCR Alpha-tocopherol 32154163 Leukemia Homo sapiens synergy NRF2 Downregulation Front Oncol Acute promyelocytic leukemia cell HL-60 RT-PCR Alpha-tocopherol 29697268 Liver-toxicity Homo sapiens detoxicity NRF2 Downregulation Nutr Cancer Liver cell Chang liver cell RT-PCR Alpha-tocopherol 29297235 Heart-toxicity Rattus norvegicus detoxicity Ros1 Upregulation Toxicol Mech Methods Heart myoblast H9C2 Kit Alpha-tocopherol 29697268 Liver-toxicity Homo sapiens detoxicity ROS1 Upregulation Nutr Cancer Liver cell Chang liver cell Kit AMN107 23883479 Leukemia Homo sapiens synergy ABL1 Phosphorylation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 Western blot AMN107 23883479 Leukemia Homo sapiens synergy ATF6 Downregulation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 Western blot AMN107 23883479 Leukemia Homo sapiens synergy CASP3 Downregulation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 Western blot AMN107 23883479 Leukemia Homo sapiens synergy CASP9 Upregulation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 Western blot AMN107 23883479 Leukemia Homo sapiens synergy CRK Phosphorylation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 Western blot AMN107 23883479 Leukemia Homo sapiens synergy FOS Downregulation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 Western blot AMN107 23883479 Leukemia Homo sapiens synergy JUN Upregulation,Phosphorylation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 Western blot AMN107 23883479 Leukemia Homo sapiens synergy XBP1 Upregulation Exp Biol Med (Maywood) Chronic myelogenous leukemia cell K-562 QRT-PCR Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy AMPK Downregulation Pharmazie Acute promyelocytic leukemia cell HL-60 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy AMPK Upregulation Pharmazie Acute promyelocytic leukemia cell NB4 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy MTOR Dephosphorylation Pharmazie Acute promyelocytic leukemia cell HL-60 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy MTOR Dephosphorylation Pharmazie Acute promyelocytic leukemia cell NB4 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy PRAM1 Downregulation Pharmazie Acute promyelocytic leukemia cell NB4 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy PRKAA1 Dephosphorylation Pharmazie Acute promyelocytic leukemia cell HL-60 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy PRKAA1 Dephosphorylation Pharmazie Acute promyelocytic leukemia cell NB4 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy TSC2 Upregulation Pharmazie Acute promyelocytic leukemia cell HL-60 Western blot Amp-activated-protein-kinase-(ampk)-activator-5-amino-4-imidazolecarboxamide-riboside 23469683 Leukemia Homo sapiens synergy TSC2 Downregulation Pharmazie Acute promyelocytic leukemia cell NB4 Western blot Andrographolide 29207612 Liver-cancer Homo sapiens synergy CASP3 Upregulation Oncotarget - - Western blot Andrographolide 29207612 Liver-cancer Homo sapiens synergy CASP3 Downregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Andrographolide 29207612 Liver-cancer Homo sapiens synergy CASP3 Upregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Andrographolide 29207612 Liver-cancer Homo sapiens synergy EPHB4 Downregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot, IHC, RT-PCR Anisomycin 16734734 Myeloma Homo sapiens synergy - - Cancer Sci Myeloma cell XG-7 - Anisomycin 16734734 Myeloma Homo sapiens synergy IKAPPAB Phosphorylation Cancer Sci Multiple myeloma cell ILKM-3 Western blot Anisomycin 16734734 Myeloma Homo sapiens synergy IKAPPAB Dephosphorylation Cancer Sci Myeloma cell U266 Western blot Anisomycin 16734734 Myeloma Homo sapiens synergy IKAPPAB Phosphorylation Cancer Sci Myeloma cell XG-7 Western blot Aprepitant 30145367 Leukemia Homo sapiens synergy - - Int J Biochem Cell Biol Acute promyelocytic leukemia cell NB4 - Aprepitant 29389803 Leukemia Homo sapiens synergy - - Anticancer Drugs Acute promyelocytic leukemia cell NB4 - Arachidonic-acid 20066898 Leukemia Homo sapiens synergy - - Oncol Res Burkitt's lymphoma cell Daudi - Arachidonic-acid 20066898 Leukemia Homo sapiens synergy - - Oncol Res Acute promyelocytic leukemia cell HL-60 - Arachidonic-acid 20066898 Leukemia Homo sapiens synergy - - Oncol Res Leukemia cell SH-1 - Arachidonic-acid 20066898 Colorectal-cancer Homo sapiens synergy - - Oncol Res Colorectal adenocarcinoma cell HT-29 - Arachidonic-acid 20066898 Colorectal-cancer Homo sapiens synergy - - Oncol Res Colorectal cancer cell LS 174T - Arachidonic-acid 20066898 Breast-cancer Homo sapiens synergy - - Oncol Res Breast cancer cell SK-BR-3 - Arachidonic-acid 20066898 Prostate-cancer Homo sapiens synergy - - Oncol Res Prostate carcinoma cell PC-3 - Arsenicum-album-30 11068345 Liver-toxicity Mus musculus detoxicity - - Complement Ther Med - - - Arsenicum-album-30 11068345 Reproductive-toxicity Mus musculus detoxicity - - Complement Ther Med - - - Arsenicum-album-30 10444909 Genotoxicity Mus musculus detoxicity - - Complement Ther Med - - - Arsenicum-album-30 10361568 Liver-toxicity Mus musculus detoxicity - - Complement Ther Med - - - Artemisinin 30179145 Breast-cancer Homo sapiens synergy - - Anticancer Agents Med Chem Lung adenocarcinoma cell A549 - Artemisinin 30179145 Liver-cancer Homo sapiens synergy - - Anticancer Agents Med Chem Hepatocellular carcinoma cell HEPG2 - Artemisinin 30179145 Cervical-cancer Homo sapiens synergy ROS1 Upregulation Anticancer Agents Med Chem Cervical adenocarcinoma cell HeLa Kit Artesunate 23906016 Leukemia Homo sapiens synergy - - Leuk Lymphoma Chronic myelogenous leukemia cell K-562 - Artesunate 23906016 Leukemia Homo sapiens synergy - - Leuk Lymphoma Histiocytic lymphoma cell U-937 - As601245 16972261 Leukemia Homo sapiens synergy - - J Cell Physiol Acute promyelocytic leukemia cell NB4 - As601245 16972261 Leukemia Homo sapiens synergy - - J Cell Physiol Histiocytic lymphoma cell U-937 - Ascorbate 28427227 Leukemia Homo sapiens synergy - - Oncotarget Acute promyelocytic leukemia cell NB4 - Ascorbate 28427227 Leukemia Homo sapiens synergy - - Oncotarget Biphenotypic B myelomonocytic leukemia cell MV-4-11 - Ascorbic-acid 20356860 Liver-toxicity Rattus norvegicus detoxicity - - Toxicol Ind Health - - - Ascorbic-acid 20098508 Leukemia Homo sapiens synergy - - Arch Drug Inf Acute promyelocytic leukemia cell HL-60 - Ascorbic-acid 19298852 Melanoma Homo sapiens synergy - - Free Radic Biol Med Melanoma cell C21/GGT - Ascorbic-acid 19298852 Melanoma Homo sapiens synergy - - Free Radic Biol Med Melanoma cell C21/BASAL - Ascorbic-acid 18715643 Liver-toxicity Mus musculus detoxicity - - Ecotoxicol Environ Saf - - - Ascorbic-acid 18715643 Liver-toxicity Mus musculus detoxicity - - Ecotoxicol Environ Saf - - - Ascorbic-acid 18418892 Leukemia Homo sapiens synergy - - J Biochem Mol Toxicol Acute promyelocytic leukemia cell HL-60 - Ascorbic-acid 26549974 Leukemia Homo sapiens synergy - - Met Ions Biol Med Acute promyelocytic leukemia cell HL-60 - Ascorbic-acid 17587338 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell RPMI 8226 - Ascorbic-acid 17587338 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell U266 - Ascorbic-acid 17477310 Liver-toxicity Rattus norvegicus detoxicity - - Indian J Exp Biol - - - Ascorbic-acid 17477310 Kidney-toxicity Rattus norvegicus detoxicity - - Indian J Exp Biol - - - Ascorbic-acid 12750841 Leukemia Homo sapiens synergy - - Cancer Chemother Pharmacol Acute lymphoblastic leukemia cell MOLT-4 - Ascorbic-acid 11468182 Myeloma Homo sapiens synergy - - Blood Myeloma cell RPMI 8226 - Ascorbic-acid 11468182 Myeloma Homo sapiens synergy - - Blood Myeloma cell U266 - Ascorbic-acid 9864170 Leukemia Homo sapiens synergy - - Blood B-lymphocyte SU-DHL-4 - Ascorbic-acid 9864170 Leukemia Homo sapiens synergy - - Blood Acute promyelocytic leukemia cell HL-60 - Ascorbic-acid 23950573 Reproductive-toxicity Rattus norvegicus detoxicity - - J Basic Clin Physiol Pharmacol - - - Ascorbic-acid 19298852 Melanoma Homo sapiens synergy BCL2 Upregulation Free Radic Biol Med Melanoma cell C21/GGT Western blot Ascorbic-acid 16867262 Liver-cancer Homo sapiens synergy BCL2 Downregulation Acta Pharmacol Sin Hepatocellular carcinoma cell HEPG2 Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy CASP3 Upregulation Free Radic Biol Med Melanoma cell C21/GGT Western blot Ascorbic-acid 16867262 Liver-cancer Homo sapiens synergy CASP3 Upregulation Acta Pharmacol Sin Hepatocellular carcinoma cell HEPG2 Western blot Ascorbic-acid 9864170 Leukemia Homo sapiens synergy CASP3 Downregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy CAT Downregulation Free Radic Biol Med Melanoma cell C21/GGT Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy CAT Upregulation Free Radic Biol Med Melanoma cell C21/BASAL Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy Cytochrome c Upregulation Free Radic Biol Med Melanoma cell C21/GGT Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy Cytochrome c Upregulation Free Radic Biol Med Melanoma cell C21/BASAL Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy H2AX Upregulation Free Radic Biol Med Melanoma cell C21/GGT Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy H2AX Upregulation Free Radic Biol Med Melanoma cell C21/BASAL Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy MAP1LC3A Upregulation Free Radic Biol Med Melanoma cell C21/GGT Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy MAP1LC3A Upregulation Free Radic Biol Med Melanoma cell C21/BASAL Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy P53 Phosphorylation Free Radic Biol Med Melanoma cell C21/BASAL Western blot Ascorbic-acid 20171736 Leukemia Homo sapiens synergy PARP1 Upregulation Leuk Res B-lymphocyte b-lymphocyte Western blot Ascorbic-acid 9864170 Leukemia Homo sapiens synergy PARP1 Downregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy PASK1 Upregulation Free Radic Biol Med Melanoma cell C21/GGT Western blot Ascorbic-acid 19298852 Melanoma Homo sapiens synergy PASK1 Downregulation Free Radic Biol Med Melanoma cell C21/BASAL Western blot Aspirin 27263286 Liver-cancer Homo sapiens synergy HO1 Upregulation Sichuan Da Xue Xue Bao Yi Xue Ban Hepatocellular carcinoma cell HEPG2 Western blot Aspirin 27263286 Liver-cancer Homo sapiens synergy NRF2 Upregulation Sichuan Da Xue Xue Bao Yi Xue Ban Hepatocellular carcinoma cell HEPG2 Western blot Aspirin 27263286 Liver-cancer Homo sapiens synergy ROS1 Upregulation Sichuan Da Xue Xue Bao Yi Xue Ban Hepatocellular carcinoma cell HEPG2 Kit Astaxanthin 24611105 Kidney-toxicity Rattus norvegicus detoxicity - - Nutr Res Pract - - - Astaxanthin 24611105 Kidney-toxicity Rattus norvegicus detoxicity Ros1 Upregulation Nutr Res Pract - - Kit Atrazine 11678611 Liver-cancer Homo sapiens synergy - - Mol Cell Biochem Hepatocellular carcinoma cell HEPG2 - Azacytidine 25953102 Leukemia Homo sapiens synergy - - J Hematol Oncol Acute promyelocytic leukemia cell NB4 - Azacytidine 25953102 Leukemia Homo sapiens synergy - - J Hematol Oncol Acute promyelocytic leukemia cell HL-60 - Azacytidine 25953102 Leukemia Homo sapiens synergy - - J Hematol Oncol Chronic myelogenous leukemia cell K-562 - Azacytidine 25953102 Leukemia Homo sapiens synergy - - J Hematol Oncol Acute myeloid leukemia cell OCI-AML3 - Bacillus calmette-guerin 30257321 Bladder-cancer Homo sapiens synergy IER3 Downregulation Biomed Pharmacother Bladder carcinoma cell 5637 QRT-PCR,Western blot Bacillus calmette-guerin 30257321 Bladder-cancer Homo sapiens synergy IL6 Upregulation Biomed Pharmacother Bladder carcinoma cell 5637 QRT-PCR, ELISA Bacillus calmette-guerin 30257321 Bladder-cancer Homo sapiens synergy IL8 Upregulation Biomed Pharmacother Bladder carcinoma cell 5637 QRT-PCR, ELISA Bacillus calmette-guerin 30257321 Bladder-cancer Homo sapiens synergy NQO1 Upregulation Biomed Pharmacother Bladder carcinoma cell 5637 QRT-PCR,Western blot Bacillus calmette-guerin 30257321 Bladder-cancer Homo sapiens synergy NRF2 Upregulation Biomed Pharmacother Bladder carcinoma cell 5637 QRT-PCR,Western blot Baicalin 33402461 Vascular-toxicity Homo sapiens detoxicity - - In Vivo Umbilical vein endothelial cell HUVECs - BCNU 22001324 Nasopharyngeal-cancer Homo sapiens synergy - - Free Radic Biol Med Nasopharyngeal carcinoma cell HONE-1 - BCNU 22001324 Lung-cancer Homo sapiens synergy - - Free Radic Biol Med Large cell lung cancer cell H460 - Benzo(a)pyrene 24061964 Lung-cancer Homo sapiens synergy - - Biol Trace Elem Res Lung adenocarcinoma cell A549 - Berbamine 19960011 Myeloma Homo sapiens synergy - - Acta Pharmacol Sin Myeloma cell KM3 - Berberine 19096576 Brain-cancer Homo sapiens synergy BCL2 Downregulation J Korean Neurosurg Soc Neuroblastoma cell SH-SY5Y Western blot Berberine 19096576 Brain-cancer Homo sapiens synergy BCL2L1 Downregulation J Korean Neurosurg Soc Neuroblastoma cell SH-SY5Y Western blot Berberine 19096576 Brain-cancer Homo sapiens synergy BID Downregulation J Korean Neurosurg Soc Neuroblastoma cell SH-SY5Y Western blot Berberine 19096576 Brain-cancer Homo sapiens synergy CASP3 Downregulation J Korean Neurosurg Soc Neuroblastoma cell SH-SY5Y Western blot Berberine 19096576 Brain-cancer Homo sapiens synergy CASP9 Downregulation J Korean Neurosurg Soc Neuroblastoma cell SH-SY5Y Western blot Berberine 18294404 Brain-cancer Rattus norvegicus synergy Mmp2 Downregulation BMC Cancer Glioma cell C6 Western blot Berberine 18294404 Brain-cancer Homo sapiens synergy MMP2 Downregulation BMC Cancer Glioma cell U87 Western blot Berberine 31332900 Pancreas-toxicity Rattus norvegicus detoxicity Sirt3 Upregulation J Biochem Mol Toxicol - - ELISA Beta-carotene 25542264 Liver-toxicity Mus musculus detoxicity - - Biol Trace Elem Res - - - Beta-carotene 25542264 Kidney-toxicity Mus musculus detoxicity - - Biol Trace Elem Res - - - BIBR1532 23293885 Leukemia Homo sapiens synergy - - Anticancer Agents Med Chem Acute promyelocytic leukemia cell NB4 - BIBR1532 23293885 Leukemia Homo sapiens synergy BCL2 Downregulation Anticancer Agents Med Chem Acute promyelocytic leukemia cell NB4 QRT-PCR BIBR1532 23293885 Leukemia Homo sapiens synergy HTERT Downregulation Anticancer Agents Med Chem Acute promyelocytic leukemia cell NB4 QRT-PCR BIBR1532 23293885 Leukemia Homo sapiens synergy MYC Downregulation Anticancer Agents Med Chem Acute promyelocytic leukemia cell NB4 QRT-PCR BIBR1532 23293885 Leukemia Homo sapiens synergy P21 Upregulation Anticancer Agents Med Chem Acute promyelocytic leukemia cell NB4 QRT-PCR BKM120 31539632 Breast-cancer Homo sapiens synergy - - Int J Biochem Cell Biol Breast cancer cell MCF7 - BKM120 31539632 Breast-cancer Homo sapiens synergy - - Int J Biochem Cell Biol Breast cancer cell MCF7 - BKM120 30316766 Leukemia Homo sapiens synergy - - Eur J Pharmacol Acute promyelocytic leukemia cell NB4 - BKM120 30316766 Leukemia Homo sapiens synergy AKT1 Phosphorylation,Downregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 Western blot BKM120 31539632 Breast-cancer Homo sapiens synergy BAD Upregulation Int J Biochem Cell Biol Breast cancer cell MCF7 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy BAD Upregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 QRT-PCR BKM120 31539632 Breast-cancer Homo sapiens synergy BCL2 Downregulation Int J Biochem Cell Biol Breast cancer cell MCF7 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy BCL2 Downregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy BIRC3 Downregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy CASP3 Upregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 Kit BKM120 31539632 Breast-cancer Homo sapiens synergy ClAP1 Downregulation Int J Biochem Cell Biol Breast cancer cell MCF7 QRT-PCR BKM120 31539632 Breast-cancer Homo sapiens synergy FOXO3a Upregulation Int J Biochem Cell Biol Breast cancer cell MCF7 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy HTERT Downregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy MCL1 Downregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy ROS1 Upregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 Kit BKM120 30316766 Leukemia Homo sapiens synergy SIRT1 Downregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 QRT-PCR BKM120 30316766 Leukemia Homo sapiens synergy XIAP Downregulation Eur J Pharmacol Acute promyelocytic leukemia cell NB4 QRT-PCR Blue-led 30745828 Bone-cancer Homo sapiens synergy - - Int J Biol Sci Osteosarcoma cell U-2 OS - BO-1012 20454509 Lung-cancer Homo sapiens synergy - - Neoplasia Large cell lung cancer cell H460 - BO-1012 20454509 Bladder-cancer Homo sapiens synergy - - Neoplasia Bladder transitional carcinoma cell NTUB1 - BO-1012 20454509 Lung-cancer Homo sapiens synergy - - Neoplasia Lung cancer cell NCI-H1299 - BO-1012 20454509 Prostate-cancer Homo sapiens synergy - - Neoplasia Prostate carcinoma cell PC-3 - BO-1012 20454509 Breast-cancer Homo sapiens synergy - - Neoplasia Breast cancer cell MCF7 - BO-1012 20454509 Laryngeal-cancer Homo sapiens synergy - - Neoplasia Gingival squamous cell carcinoma cell OEC-M1 - Bortezomib 22922937 Myeloma Homo sapiens synergy - - Oncol Rep Multiple myeloma cell PCNY-1 - Bortezomib 21569716 Leukemia Homo sapiens synergy - - Zhonghua Xue Ye Xue Za Zhi Acute promyelocytic leukemia cell NB4 - Bortezomib 20510040 Myeloma Homo sapiens synergy - - Zhonghua Xue Ye Xue Za Zhi Myeloma cell KM3 - Bortezomib 20471514 Leukemia Homo sapiens synergy - - Cancer Genet Cytogenet Acute promyelocytic leukemia cell HL-60 - Bortezomib 19016012 Myeloma Homo sapiens synergy - - Med Oncol Myeloma cell RPMI 8226 - Bortezomib 19016012 Lymphoma Homo sapiens synergy - - Med Oncol Histiocytic lymphoma cell U-937 - Bortezomib 19016012 Lymphoma Homo sapiens synergy - - Med Oncol Lymphoma cell U-937-vcr - Bortezomib 19016012 Lung-cancer Homo sapiens synergy - - Med Oncol Small cell lung cancer cell NCI-H69 - Bortezomib 19016012 Lung-cancer Homo sapiens synergy - - Med Oncol Small cell lung cancer cell H69AR - Bortezomib 19016012 Kidney-cancer Homo sapiens synergy - - Med Oncol Renal cell adenocarcinoma cell ACHN - Bortezomib 19016012 Leukemia Homo sapiens synergy - - Med Oncol Acute lymphoblastic leukemia cell CCRF-CEM - Bortezomib 18315906 Myeloma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell RPMI 8226 - Bortezomib 18315906 Myeloma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell CZ-1 - Bortezomib 18315906 Myeloma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell NCI-H929 - Bortezomib 18024285 Leukemia Homo sapiens synergy - - Nan Fang Yi Ke Da Xue Xue Bao Leukemia cell BCR/ABL+-CD34+ - Bortezomib 17959525 Leukemia Homo sapiens synergy - - Nan Fang Yi Ke Da Xue Xue Bao Acute promyelocytic leukemia cell HL-60 - Bortezomib 17666343 Leukemia Homo sapiens synergy - - Nan Fang Yi Ke Da Xue Xue Bao Acute promyelocytic leukemia cell HL-60 - Bortezomib 17587338 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell RPMI 8226 - Bortezomib 17587338 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell U266 - Bortezomib 17495969 Leukemia Homo sapiens synergy - - Leukemia Acute promyelocytic leukemia cell NB4 - Bortezomib 17495969 Leukemia Homo sapiens synergy - - Leukemia Chronic myelogenous leukemia cell K-562 - Bortezomib 26310857 Lymphoma Homo sapiens synergy - - Cancer Med Lymphoma cell JeKo-1 - Bortezomib 26310857 Lymphoma Homo sapiens synergy - - Cancer Med Mantle cell lymphoma cell GRANTA- 519 - Bortezomib 26310857 Lymphoma Homo sapiens synergy - - Cancer Med Bone marrow mononuclear cell BMMCs - Bortezomib 25913414 Leukemia Homo sapiens synergy - - Turk J Haematol Myelodysplastic cell P39 - Bortezomib 24939418 Leukemia Homo sapiens synergy - - Mol Med Rep Chronic myelogenous leukemia cell K-562 - Bortezomib 23877794 Brain-cancer Homo sapiens synergy - - Leukemia Osteosarcoma cell U-2 OS - Bortezomib 23877794 Leukemia Homo sapiens synergy - - Leukemia Chronic myelogenous leukemia cell K-562 - Bortezomib 23877794 Leukemia Homo sapiens synergy - - Leukemia Acute myeloid leukemia cell OCI-AML3 - Bortezomib 24939418 Leukemia Homo sapiens synergy ABL1 Downregulation Mol Med Rep Chronic myelogenous leukemia cell K-562 QRT-PCR,Western blot Bortezomib 22391178 Myeloma Homo sapiens synergy BCL-XL Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell KM3 RT-PCR Bortezomib 19608275 Myeloma Homo sapiens synergy BCL2 Downregulation Leuk Res Myeloma cell RPMI 8226 Western blot Bortezomib 24377552 Myeloma Homo sapiens synergy BCL2 Downregulation Asian Pac J Cancer Prev Myeloma cell RPMI 8226 Western blot Bortezomib 22391178 Myeloma Homo sapiens synergy Bim Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell KM3 RT-PCR Bortezomib 19608275 Myeloma Homo sapiens synergy BIM Upregulation Leuk Res Myeloma cell RPMI 8226 Western blot Bortezomib 26310857 Lymphoma Homo sapiens synergy BIM Downregulation Cancer Med Lymphoma cell JeKo-1 Western blot Bortezomib 20471514 Leukemia Homo sapiens synergy CASP3 Upregulation Cancer Genet Cytogenet Acute promyelocytic leukemia cell HL-60 Kit Bortezomib 22391178 Myeloma Homo sapiens synergy CASP3 Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell KM3 RT-PCR Bortezomib 22922937 Myeloma Homo sapiens synergy CASP3 Upregulation Oncol Rep Multiple myeloma cell KMS-11 Western blot Bortezomib 24377552 Myeloma Homo sapiens synergy CASP3 Downregulation Asian Pac J Cancer Prev Myeloma cell RPMI 8226 Western blot Bortezomib 20471514 Leukemia Homo sapiens synergy CASP8 Upregulation Cancer Genet Cytogenet Acute promyelocytic leukemia cell HL-60 Kit Bortezomib 24377552 Myeloma Homo sapiens synergy CASP8 Upregulation Asian Pac J Cancer Prev Myeloma cell RPMI 8226 Western blot Bortezomib 20471514 Leukemia Homo sapiens synergy CASP9 Upregulation Cancer Genet Cytogenet Acute promyelocytic leukemia cell HL-60 Kit Bortezomib 26310857 Lymphoma Homo sapiens synergy CASP9 Upregulation Cancer Med Lymphoma cell JeKo-1 Western blot Bortezomib 24377552 Myeloma Homo sapiens synergy CASP9 Upregulation Asian Pac J Cancer Prev Myeloma cell RPMI 8226 Western blot Bortezomib 18485479 Myeloma Homo sapiens synergy CTNNB1 Downregulation Leuk Res Myeloma cell RPMI 8226 QRT-PCR, Western blot, ELISA Bortezomib 18485479 Myeloma Homo sapiens synergy CTNNB1 Downregulation Leuk Res Myeloma cell CZ-1 QRT-PCR, Western blot, ELISA Bortezomib 18485479 Myeloma Homo sapiens synergy CTNNB1 Downregulation Leuk Res Myeloma cell NCI-H929 QRT-PCR, Western blot, ELISA Bortezomib 18485479 Myeloma Homo sapiens synergy CTNNB1 Downregulation Leuk Res Myeloma cell LP1 QRT-PCR, Western blot, ELISA Bortezomib 18485479 Myeloma Homo sapiens synergy CTNNB1 Downregulation Leuk Res Myeloma cell U266 QRT-PCR, Western blot, ELISA Bortezomib 20471514 Leukemia Homo sapiens synergy HRK Upregulation Cancer Genet Cytogenet Acute promyelocytic leukemia cell HL-60 QRT-PCR Bortezomib 19608275 Myeloma Homo sapiens synergy HSP27 Upregulation,Phosphorylation Leuk Res Myeloma cell RPMI 8226 Western blot Bortezomib 22922937 Myeloma Homo sapiens synergy HSP90 Upregulation Oncol Rep Multiple myeloma cell KMS-11 Western blot Bortezomib 19608275 Myeloma Homo sapiens synergy JNK Upregulation,Phosphorylation Leuk Res Myeloma cell RPMI 8226 Western blot Bortezomib 21867610 Leukemia Homo sapiens synergy LIVIN Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Leukemia cell Jurkat RT-PCR Bortezomib 23257433 Leukemia Homo sapiens synergy NFKB Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 SP 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QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy AKT1 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy AKT1 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy AKT1 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy ATG4B Upregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy ATG4B Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy ATG4B Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy ATG5 Upregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy ATG5 Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy ATG5 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy ATG5 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy ATG5 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy ATG5 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy ATGB Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy ATGB Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy ATGB Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy BAX Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy BAX Upregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy BAX Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy BAX Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy BCL2 Downregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy BCL2 Downregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy BCL2 Downregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy BCL2 Downregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy BECN1 Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy BECN1 Upregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy BECN1 Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy BECN1 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy BECN1 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy BECN1 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy CASP3 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 30543957 Immune-toxicity Gallus gallus synergy CASP3 Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy CASP3 Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy CASP3 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy CASP8 Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy CASP8 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 30543957 Immune-toxicity Gallus gallus synergy CASP8 Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy CASP8 Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy CASP9 Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy CASP9 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 30543957 Immune-toxicity Gallus gallus synergy CASP9 Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy CASP9 Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy COX2 Upregulation J Inorg Biochem - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy COX2 Upregulation J Inorg Biochem - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy COX2 Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy COX2 Upregulation Biol Trace Elem Res - - QRT-PCR,Western blot CuSO4 30145471 Immune-toxicity Gallus gallus synergy COX2 Upregulation Int Immunopharmacol - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy COX2 Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy COX2 Upregulation Ecotoxicol Environ Saf - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy Cytochrome c Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy Cytochrome c Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 29569195 Liver-toxicity Gallus gallus synergy Cytochrome c Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy Drp1 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 30543957 Immune-toxicity Gallus gallus synergy DRP1 Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy DRP1 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy DYNEIN Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy FAS Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy FAS Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 29569195 Liver-toxicity Gallus gallus synergy FAS Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy HSP60 Upregulation Biol Trace Elem Res - - QRT-PCR,Western blot CuSO4 30145471 Immune-toxicity Gallus gallus synergy HSP60 Upregulation Int Immunopharmacol - - QRT-PCR,Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy HSP60 Upregulation Ecotoxicol Environ Saf - - QRT-PCR, Western blot CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy HSP70 Upregulation Biol Trace Elem Res - - QRT-PCR,Western blot CuSO4 30145471 Immune-toxicity Gallus gallus synergy HSP70 Upregulation Int Immunopharmacol - - QRT-PCR,Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy HSP70 Upregulation Ecotoxicol Environ Saf - - QRT-PCR, Western blot CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy HSP90 Upregulation Biol Trace Elem Res - - QRT-PCR,Western blot CuSO4 30145471 Immune-toxicity Gallus gallus synergy HSP90 Upregulation Int Immunopharmacol - - QRT-PCR,Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy HSP90 Upregulation Ecotoxicol Environ Saf - - QRT-PCR, Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy IFNG Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IFNG Downregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IFNG Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL10 Downregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IL10 Downregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IL10 Downregulation Int Immunopharmacol - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy Il12B Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL12B Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IL12B Downregulation Biol Trace Elem Res - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL17 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IL17 Upregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IL17 Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL1B Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IL1B Upregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IL1B Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL2 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IL2 Upregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IL2 Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL4 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IL4 Downregulation Int Immunopharmacol - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL6 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IL6 Upregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IL6 Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31896471 Immune-toxicity Gallus gallus synergy IL8 Upregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy IL8 Upregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy IL8 Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy INOS Upregulation Biol Trace Elem Res - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy INOS Upregulation Int Immunopharmacol - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy INOS Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy INOS Upregulation Ecotoxicol Environ Saf - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy MAP1LC3A Upregulation J Inorg Biochem - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy MAP1LC3A Upregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy MAP1LC3A Upregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy MAP1LC3A Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy MAP1LC3A Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy MAP1LC3A Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy MAP1LC3A Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy MFN1 Downregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy MFN1 Downregulation Chemosphere - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy MFN1 Downregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy MFN2 Downregulation J Inorg Biochem - - QRT-PCR CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy MFN2 Downregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy MFN2 Downregulation Chemosphere - - QRT-PCR,Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy MTOR Downregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy MTOR Downregulation J Inorg Biochem - - Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy MTORC Downregulation J Inorg Biochem - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy MTORC Downregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy MTORC Downregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy NFKB Upregulation Biol Trace Elem Res - - QRT-PCR,Western blot CuSO4 30145471 Immune-toxicity Gallus gallus synergy NFKB Upregulation Int Immunopharmacol - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy NFKB Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy NFKB Upregulation Ecotoxicol Environ Saf - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy NFKB Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy NFKB Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy NFKB Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy OPA1 Downregulation Ecotoxicol Environ Saf - - QRT-PCR CuSO4 30543957 Immune-toxicity Gallus gallus synergy OPA1 Downregulation Chemosphere - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy OPA1 Downregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31557571 Gastrointestinal-toxicity Gallus gallus synergy p53 Upregulation Ecotoxicol Environ Saf - - QRT-PCR,Western blot CuSO4 30543957 Immune-toxicity Gallus gallus synergy P53 Upregulation Chemosphere - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy P53 Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy P53 Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy PI3K Upregulation J Inorg Biochem - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy PI3K Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy PI3K Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy PI3K Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy PTGES Upregulation Biol Trace Elem Res - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy PTGES Upregulation J Inorg Biochem - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy PTGES Upregulation J Inorg Biochem - - QRT-PCR CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy PTGES Upregulation J Inorg Biochem - - QRT-PCR CuSO4 30145471 Immune-toxicity Gallus gallus synergy PTGES Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 30543957 Immune-toxicity Gallus gallus synergy SOD Downregulation Chemosphere - - Kit CuSO4 30145471 Immune-toxicity Gallus gallus synergy TNF Upregulation Int Immunopharmacol - - QRT-PCR CuSO4 31473897 Gastrointestinal-toxicity Gallus gallus synergy TNF Upregulation Biol Trace Elem Res - - QRT-PCR,Western blot CuSO4 29569195 Liver-toxicity Gallus gallus synergy TNF Upregulation Environ Sci Pollut Res Int - - QRT-PCR,Western blot CuSO4 31896471 Immune-toxicity Gallus gallus synergy TNF Upregulation Ecotoxicol Environ Saf - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy TNF Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy TNF Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 29054015 Neuronal-toxicity Gallus gallus synergy TNF Upregulation J Inorg Biochem - - QRT-PCR, Western blot CuSO4 31945648 Immune-toxicity Gallus gallus synergy TORC1 Downregulation J Inorg Biochem - - QRT-PCR CuSO4 31945648 Immune-toxicity Gallus gallus synergy TORC2 Downregulation J Inorg Biochem - - QRT-PCR Cyclopamine 26458318 Prostate-cancer Homo sapiens synergy GLI1 Downregulation Neoplasma Prostate carcinoma cell PC-3 QRT-PCR,Western blot, IFA Cyclopamine 26458318 Prostate-cancer Homo sapiens synergy PTCH Downregulation Neoplasma Prostate carcinoma cell PC-3 QRT-PCR,Western blot, IFA Cyclopamine 26458318 Prostate-cancer Homo sapiens synergy SMO Downregulation Neoplasma Prostate carcinoma cell PC-3 Western blot, IFA Cyclophosphamide 17204170 Leukemia Homo sapiens synergy TERT Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 Southern blot, ELISA Daunorubicin 15067736 Leukemia Homo sapiens synergy - - Zhejiang Da Xue Xue Bao Yi Xue Ban Acute non-promyelocytic leukemia cell ANPL - Daunorubicin 26051726 Leukemia Homo sapiens synergy - - Pak J Pharm Sci Acute promyelocytic leukemia cell APL - Daunorubicin 26051726 Leukemia Homo sapiens synergy ANXA2 Downregulation Pak J Pharm Sci Acute promyelocytic leukemia cell NB4 ELISA Daunorubicin 26051726 Leukemia Homo sapiens synergy TISSUE FACTOR Downregulation Pak J Pharm Sci Acute promyelocytic leukemia cell NB4 ELISA Decitabine 27812249 Leukemia Homo sapiens synergy - - Indian J Hematol Blood Transfus Myelodysplastic syndrome cell SKM-1 - Decitabine 27784354 Leukemia Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Biphenotypic B myelomonocytic leukemia cell MV-4-11 - Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy - - J Investig Med Myelodysplastic syndrome cell MUTZ-1 - Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy - - J Investig Med Myelodysplastic syndrome cell SKM-1 - Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy AKT1 Downregulation J Investig Med Myelodysplastic syndrome cell MUTZ-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy AKT1 Downregulation J Investig Med Myelodysplastic syndrome cell SKM-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy ATF6 Upregulation J Investig Med Myelodysplastic syndrome cell MUTZ-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy ATF6 Upregulation J Investig Med Myelodysplastic syndrome cell SKM-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy BCL2 Upregulation J Investig Med Myelodysplastic syndrome cell MUTZ-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy BCL2 Upregulation J Investig Med Myelodysplastic syndrome cell SKM-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy CASP3 Upregulation J Investig Med Myelodysplastic syndrome cell MUTZ-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy CASP3 Upregulation J Investig Med Myelodysplastic syndrome cell SKM-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy CHOP Upregulation J Investig Med Myelodysplastic syndrome cell MUTZ-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy CHOP Upregulation J Investig Med Myelodysplastic syndrome cell SKM-1 Western blot Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy ROS1 Upregulation J Investig Med Myelodysplastic syndrome cell MUTZ-1 Flow cytometry Decitabine 30898879 Myelodysplastic-syndrome Homo sapiens synergy ROS1 Upregulation J Investig Med Myelodysplastic syndrome cell SKM-1 Flow cytometry Deferoxamine 24908354 Leukemia Homo sapiens synergy BAX Upregulation Leuk Res Acute promyelocytic leukemia cell HL-60 IHC, IFA Deferoxamine 24908354 Leukemia Homo sapiens synergy CASP3 Upregulation Leuk Res Acute promyelocytic leukemia cell HL-60 IHC, IFA Deferoxamine 24908354 Leukemia Homo sapiens synergy KIT Downregulation Leuk Res Acute promyelocytic leukemia cell HL-60 IHC, IFA Deferoxamine 21781490 Leukemia Homo sapiens synergy NFKB Downregulation Zhonghua Xue Ye Xue Za Zhi Acute promyelocytic leukemia cell HL-60 IHC Deferoxamine 24908354 Leukemia Homo sapiens synergy SURVIVIN Downregulation Leuk Res Acute promyelocytic leukemia cell HL-60 IHC, IFA Dexamethasone 20510040 Myeloma Homo sapiens synergy - - Zhonghua Xue Ye Xue Za Zhi Myeloma cell KM3 - Dexamethasone 18088466 Myeloma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell U266 - Dexamethasone 17425992 Asthma Homo sapiens synergy - - Nan Fang Yi Ke Da Xue Xue Bao T-lymphocyte T-lymphocyte - Dichloroacetate 25982179 Leukemia Homo sapiens synergy GPX Downregulation Leuk Res Primary acute promyelocytic leukemia cell Primary APL cell Western blot Dichloroacetate 25982179 Leukemia Homo sapiens synergy MCL1 Downregulation Leuk Res Primary acute promyelocytic leukemia cell Primary APL cell Western blot Diethyldithiocarbamate 18575767 Cervical-cancer Homo sapiens synergy - - Int J Oncol Cervical adenocarcinoma cell HeLa - Diethyloxadicarbocyanine 12921855 Fibrosarcoma Homo sapiens synergy - - Eur J Pharmacol Fibrosarcoma cell HT1080 - Dihydroartemisinin 28261759 Lung-cancer Homo sapiens synergy - - Biol Trace Elem Res Lung adenocarcinoma cell A549 - Dimercaptopropanesulfonic-acid 16421177 Leukemia Homo sapiens synergy - - Toxicol Sci Acute promyelocytic leukemia cell NB4 - Dimercaptopropanesulfonic-acid 1608923 Liver-toxicity Cavia porcellus detoxicity - - Pharmacol Toxicol - - - Dimercaptopropanesulfonic-acid 1647157 Liver-toxicity Cavia porcellus detoxicity - - Arch Toxicol - - - Dimercaptosuccinic-acid 16421177 Leukemia Homo sapiens synergy - - Toxicol Sci Acute promyelocytic leukemia cell NB4 - Dimercaptosuccinic-acid 7506906 Liver-toxicity Mus musculus detoxicity - - Arch Toxicol - - - Dimercaptosuccinic-acid 1608923 Liver-toxicity Cavia porcellus detoxicity - - Pharmacol Toxicol - - - Dimercaptosuccinic-acid 1647157 Liver-toxicity Cavia porcellus detoxicity - - Arch Toxicol - - - Diphenyleneiodonium 17804067 Leukemia Homo sapiens detoxicity - - Leuk Res Acute promyelocytic leukemia cell NB4 - Dithiothreitol 18022205 Liver-cancer Homo sapiens detoxicity - - Toxicol Appl Pharmacol Hepatocellular carcinoma cell HEP3B - Dithiothreitol 16421177 Leukemia Homo sapiens synergy - - Toxicol Sci Acute promyelocytic leukemia cell NB4 - Dithiothreitol 10385689 Leukemia Homo sapiens synergy - - Mol Pharmacol Acute promyelocytic leukemia cell NB4 - Dithiothreitol 26494474 Head-and-neck-cancer Homo sapiens synergy - - Environ Toxicol Oral cancer cell Primarily cultured cell - Dithiothreitol 26494474 Head-and-neck-cancer Homo sapiens synergy BAX Upregulation Environ Toxicol Oral cancer cell Primarily cultured cell Western blot Dithiothreitol 26494474 Head-and-neck-cancer Homo sapiens synergy BCL2 Upregulation Environ Toxicol Oral cancer cell Primarily cultured cell Western blot Dithiothreitol 26494474 Head-and-neck-cancer Homo sapiens synergy GRP78 Upregulation Environ Toxicol Oral cancer cell Primarily cultured cell Western blot Dithiothreitol 26494474 Head-and-neck-cancer Homo sapiens synergy P53 Downregulation Environ Toxicol Oral cancer cell Primarily cultured cell Western blot Dl-buthionine-(s,r)-sulfoximine 19720055 Leukemia Homo sapiens synergy - - Chem Biol Interact Histiocytic lymphoma cell U-937 - Dl-buthionine-(s,r)-sulfoximine 17550858 Leukemia Homo sapiens synergy - - Haematologica Chronic myeloid leukemia cell AR230-s - Dl-buthionine-(s,r)-sulfoximine 17550858 Leukemia Homo sapiens synergy ABL1 Dephosphorylation,Upregulation Haematologica Chronic myeloid leukemia cell KCL22-r Western blot Dl-buthionine-(s,r)-sulfoximine 19720055 Leukemia Homo sapiens synergy P38 MAPK Upregulation,Phosphorylation Chem Biol Interact Histiocytic lymphoma cell U-937 Western blot Dmnq 12040405 Leukemia Homo sapiens synergy - - Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) Histiocytic lymphoma cell U-937 - Docosahexaenoic-acid 16353135 Brain-cancer Homo sapiens synergy - - Int J Cancer Neuroblastoma cell SK-N-DZ - Docosahexaenoic-acid 16353135 Brain-cancer Homo sapiens synergy - - Int J Cancer Neuroblastoma cell SH-SY5Y - Docosahexaenoic-acid 16353135 Brain-cancer Homo sapiens synergy - - Int J Cancer Neuroblastoma cell SK-N-BE(2) - Docosahexaenoic-acid 16353135 Brain-cancer Homo sapiens synergy - - Int J Cancer Neuroblastoma cell SK-N-AS - Docosahexaenoic-acid 16353135 Brain-cancer Homo sapiens synergy - - Int J Cancer Neuroblastoma cell IMR-32 - Docosahexaenoic-acid 16353135 Brain-cancer Homo sapiens synergy - - Int J Cancer Lung fibroblast cell MRC-5 - Docosahexaenoic-acid 29751151 Liver-toxicity Homo sapiens detoxicity - - Prostaglandins Other Lipid Mediat Liver cell Chang liver cell - Docosahexaenoic-acid 15382055 Colorectal-cancer Homo sapiens synergy - - Int J Cancer Colorectal adenocarcinoma cell HT-29 - Docosahexaenoic-acid 15382055 Colorectal-cancer Homo sapiens synergy - - Int J Cancer Colorectal adenocarcinoma cell SW620 - Docosahexaenoic-acid 15382055 Colorectal-cancer Homo sapiens synergy - - Int J Cancer Colorectal cancer cell LS 174T - Docosahexaenoic-acid 15382055 Breast-cancer Homo sapiens synergy - - Int J Cancer Breast adenocarcinoma cell MDA-MB-468 - 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Homo sapiens synergy AKT1 Dephosphorylation Endocr Relat Cancer Ovarian cancer cell SK-OV-3 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy AKT1 Dephosphorylation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy ATG12 Upregulation Oncotarget Prostate carcinoma cell PC-3 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy ATG12 Upregulation Oncotarget Prostate carcinoma cell LNCaP Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy ATG5 Upregulation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy BECN1 Upregulation Oncotarget Prostate carcinoma cell PC-3 QRT-PCR, Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy BECN1 Upregulation Oncotarget Prostate carcinoma cell LNCaP QRT-PCR, Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy BECN1 Downregulation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy CASP3 Upregulation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy CASP3 Upregulation Oncotarget Prostate carcinoma cell PC-3 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy CASP3 Upregulation Oncotarget Prostate carcinoma cell LNCaP Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy EIF4E1 Phosphorylation Endocr Relat Cancer Ovarian cancer cell SK-OV-3 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy EIF4E1 Phosphorylation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy EIF4EBP1 Phosphorylation Endocr Relat Cancer Ovarian cancer cell SK-OV-3 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy EIF4EBP1 Phosphorylation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy ERK1 Dephosphorylation Endocr Relat Cancer Ovarian cancer cell SK-OV-3 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy ERK1 Dephosphorylation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy JNK Downregulation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy MAP1LC3A Upregulation Endocr Relat Cancer Ovarian cancer cell SK-OV-3 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy MAP1LC3A Upregulation Oncotarget Prostate carcinoma cell PC-3 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy MAP1LC3A Upregulation Oncotarget Prostate carcinoma cell LNCaP Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy PARP1 Downregulation Endocr Relat Cancer Ovarian cancer cell SK-OV-3 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy PARP1 Upregulation Oncotarget Prostate carcinoma cell PC-3 Western blot Everolimus 28061438 Prostate-cancer Homo sapiens synergy PARP1 Upregulation Oncotarget Prostate carcinoma cell LNCaP Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy RPS6KB1 Upregulation,Phosphorylation Endocr Relat Cancer Ovarian cancer cell SK-OV-3 Western blot Everolimus 22919067 Ovary-cancer Homo sapiens synergy RPS6KB1 Dephosphorylation Endocr Relat Cancer Ovarian cancer cell OV2008 Western blot Fisetin 31638196 Leukemia Homo sapiens synergy - - Int J Oncol Chronic myelogenous leukemia cell K-562 - Fisetin 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Lung adenocarcinoma cell A549 - Fisetin 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Colon adenocarcinoma cell LoVo - Fisetin 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Breast cancer cell MCF7 - Fisetin 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Lung cancer cell 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promyelocytic leukemia cell NB4 RT-PCR Flavonoids-of-puerarin 20416161 Leukemia Homo sapiens synergy SURVIVIN Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Acute promyelocytic leukemia cell NB4 RT-PCR Flaxseed-oil 28209094 Heart-toxicity Rattus norvegicus detoxicity - - Redox Rep - - - Fludarabine 25869069 Leukemia Homo sapiens synergy BCL2 Dephosphorylation Biochem Biophys Res Commun Chronic lymphocytic leukemia cell CLL cell Western blot Fludarabine 25869069 Leukemia Homo sapiens synergy ERK1 Dephosphorylation Biochem Biophys Res Commun Chronic lymphocytic leukemia cell CLL cell Western blot Fludarabine 25869069 Leukemia Homo sapiens synergy MCL1 Dephosphorylation Biochem Biophys Res Commun Chronic lymphocytic leukemia cell CLL cell Western blot Fucoidan 27329592 Leukemia Homo sapiens synergy - - Oncotarget Acute promyelocytic leukemia cell NB4 - Fucoidan 27329592 Leukemia Homo sapiens synergy - - Oncotarget Acute myeloid leukemia cell Kasumi-1 - Galectin-3-(gal-3)-inhibition 23917726 Kidney-cancer Homo sapiens synergy ANXA7 Upregulation Cancer Biol Ther Kidney cancer cell CAKI-1 Western blot Galectin-3-(gal-3)-inhibition 23917726 Kidney-cancer Homo sapiens synergy ANXA7 Upregulation Cancer Biol Ther Kidney cancer cell CAKI-2 Western blot Galectin-3-(gal-3)-inhibition 23917726 Kidney-cancer Homo sapiens synergy ANXA7 Upregulation Cancer Biol Ther Renal cell adenocarcinoma cell 786-O Western blot Galectin-3-(gal-3)-inhibition 23917726 Kidney-cancer Homo sapiens synergy ANXA7 Upregulation Cancer Biol Ther Renal cell adenocarcinoma cell ACHN Western blot Galectin-3-(gal-3)-inhibition 23917726 Kidney-cancer Homo sapiens synergy BCL-XL Downregulation Cancer Biol Ther Kidney cancer cell CAKI-1 Western blot Galectin-3-(gal-3)-inhibition 23917726 Kidney-cancer Homo sapiens synergy BCL2 Downregulation Cancer Biol Ther Kidney cancer cell CAKI-1 Western blot Galectin-3-(gal-3)-inhibition 23917726 Kidney-cancer Homo sapiens synergy Cytochrome c Upregulation Cancer Biol 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HTERT Downregulation Mol Cell Endocrinol Breast cancer cell MCF7 QRT-PCR Human-growth-hormone 23851143 Breast-cancer Homo sapiens synergy MMP2 Downregulation Mol Cell Endocrinol Breast cancer cell MCF7 QRT-PCR Human-growth-hormone 23851143 Breast-cancer Homo sapiens synergy MMP9 Downregulation Mol Cell Endocrinol Breast cancer cell MCF7 QRT-PCR Human-growth-hormone 23851143 Breast-cancer Homo sapiens synergy MYC Upregulation Mol Cell Endocrinol Breast cancer cell MCF7 QRT-PCR Human-growth-hormone 23851143 Breast-cancer Homo sapiens synergy NOXA Upregulation Mol Cell Endocrinol Breast cancer cell MCF7 QRT-PCR Human-growth-hormone 23851143 Breast-cancer Homo sapiens synergy P53 Upregulation Mol Cell Endocrinol Breast cancer cell MCF7 QRT-PCR Human-growth-hormone 23851143 Breast-cancer Homo sapiens synergy SURVIVIN Downregulation Mol Cell Endocrinol Breast cancer cell MCF7 QRT-PCR Human-growth-hormone 23851143 Breast-cancer Homo sapiens synergy UPA Downregulation Mol Cell Endocrinol 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Icariin 23975599 Liver-cancer Homo sapiens synergy VEGF Downregulation Cell Biochem Biophys Hepatocellular carcinoma cell SMMC-7721 Western blot Icariin 23975599 Liver-cancer Homo sapiens synergy VEGF Downregulation Cell Biochem Biophys Hepatocellular carcinoma cell HEPG2 Western blot Idelalisib 28254430 Leukemia Homo sapiens synergy - - Int J Biochem Cell Biol Acute promyelocytic leukemia cell NB4 - Ifosfamide 26548578 Bone-cancer Homo sapiens synergy - - Int J Oncol Osteosarcoma cell 143B - Ifosfamide 26548578 Bone-cancer Homo sapiens synergy - - Int J Oncol Osteosarcoma cell Saos-2 - Imatinib 16917208 Leukemia Homo sapiens synergy - - Anticancer Drugs - - - Imatinib 16917208 Leukemia Homo sapiens synergy - - Anticancer Drugs - - - Imatinib 16917208 Leukemia Homo sapiens synergy - - Anticancer Drugs Chronic myelogenous leukemia cell K-562 - Imatinib 24240679 Bone-cancer Mus musculus synergy - - Oncogene - - - Imatinib-mesylate 16597375 Heart-toxicity Rattus norvegicus synergy - - J 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Imatinib-mesylate 16249384 Leukemia Homo sapiens synergy HSPA5 Upregulation Blood Chronic myelogenous leukemia cell K-562 Western blot Imatinib-mesylate 16249384 Leukemia Homo sapiens synergy PARP1 Upregulation Blood Chronic myelogenous leukemia cell K-562 Western blot Imperatorin 27608960 Heart-toxicity Rattus norvegicus detoxicity HO1 Upregulation Toxicol In Vitro Heart myoblast H9C2 RT-PCR, Western blot Imperatorin 27608960 Heart-toxicity Rattus norvegicus detoxicity Nqo1 Upregulation,Downregulation Toxicol In Vitro Heart myoblast H9C2 RT-PCR, Western blot Imperatorin 27608960 Heart-toxicity Rattus norvegicus detoxicity Nrf2 Upregulation Toxicol In Vitro Heart myoblast H9C2 RT-PCR Indomethacin 24312908 Lung-cancer Homo sapiens synergy COX2 Downregulation Biomed Res Int Lung adenocarcinoma cell A549 RT-PCR, Western blot Indomethacin 24312908 Lung-cancer Homo sapiens synergy ERK1 Downregulation,Dephosphorylation Biomed Res Int Lung adenocarcinoma cell A549 Western blot Indomethacin 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synergy PARP1 Downregulation Leukemia Lymphoma cell BC-3 Western blot Interferon-alpha 24250827 Lymphoma Homo sapiens synergy PARP1 Downregulation PLoS One Lymphoma cell BC-3 Western blot Interferon-alpha 11023521 Leukemia Homo sapiens synergy TAX Downregulation Blood Lymphoma cell HuT 102 Western blot Interferon-alpha 11023521 Leukemia Homo sapiens synergy TAX Downregulation Blood T cell leukemia cell MT-2 Western blot Interferon-alpha 12560223 Leukemia Homo sapiens synergy TNF Downregulation Blood Lymphoma cell HuT 102 RT-PCR Interferon-gamma 12917339 Leukemia Homo sapiens synergy - - Mol Cell Biol Embryonic kidney cell HEK-293 - Interferon-gamma 12917339 Cervical-cancer Homo sapiens synergy - - Mol Cell Biol Cervical adenocarcinoma cell HeLa - Irradiation 22363680 Prostate-cancer Homo sapiens synergy - - PLoS One Prostate carcinoma cell LNCaP - Irradiation 22363680 Prostate-cancer Homo sapiens synergy - - PLoS One Prostate carcinoma cell PC-3 - Irradiation 21741957 Leukemia Homo 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Irradiation 19242099 Brain-cancer Homo sapiens synergy PDK1 Phosphorylation Autophagy Glioblastoma cell U-118MG Western blot Irradiation 19242099 Brain-cancer Homo sapiens synergy PI3K Downregulation Autophagy Glioblastoma cell U-118MG Western blot Irradiation 19242099 Brain-cancer Homo sapiens synergy PTEN Phosphorylation Autophagy Glioblastoma cell U-118MG Western blot Irradiation 22363680 Prostate-cancer Homo sapiens synergy RPS6KB1 Dephosphorylation PLoS One Prostate carcinoma cell LNCaP Western blot Itraconazole 27784375 Myeloma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell NCI-H929 - Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy - - Int J Oncol Normal skeletal muscle cell SKMC - Itraconazole 28823259 Leukemia Homo sapiens synergy BAX Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Acute myelogenous leukemia cell KG-1a Western blot Itraconazole 27784375 Myeloma Homo sapiens synergy BCL2 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell NCI-H929 QRT-PCR Itraconazole 28823259 Leukemia Homo sapiens synergy BCL2 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Acute myelogenous leukemia cell KG-1a Western blot Itraconazole 28823259 Leukemia Homo sapiens synergy CASP3 Upregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Acute myelogenous leukemia cell KG-1a Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CASP3 Upregulation Int J Oncol Rhabdomyosarcoma cell RD Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CASP3 Upregulation Int J Oncol Rhabdomyosarcoma cell CCA Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CASP3 Upregulation Int J Oncol Rhabdomyosarcoma cell RUCH3 Western blot Itraconazole 27784375 Myeloma Homo sapiens synergy CCND1 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell NCI-H929 QRT-PCR Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CDK2 Downregulation Int J Oncol Rhabdomyosarcoma cell SRH Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CDK2 Downregulation Int J Oncol Rhabdomyosarcoma cell RD Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CDK2 Downregulation Int J Oncol Rhabdomyosarcoma cell RUCH3 Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CDK2 Downregulation Int J Oncol Alveolar hrabdomyosarcomas cell RH-30 Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy CDK2 Upregulation Int J Oncol Rhabdomyosarcoma cell ZF Western blot Itraconazole 27784375 Myeloma Homo sapiens synergy GLI1 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell NCI-H929 QRT-PCR,Western blot Itraconazole 28823259 Leukemia Homo sapiens synergy GLI1 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Acute myelogenous leukemia cell KG-1a Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy GLI1 Downregulation Int J Oncol Rhabdomyosarcoma cell RD Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy GLI1 Downregulation Int J Oncol Rhabdomyosarcoma cell CCA Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy GLI1 Downregulation Int J Oncol Rhabdomyosarcoma cell RUCH3 Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy GLI1 Downregulation Int J Oncol Alveolar hrabdomyosarcomas cell RH-30 Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy GLI1 Downregulation Int J Oncol Rhabdomyosarcoma cell ZF Western blot Itraconazole 28823259 Leukemia Homo sapiens synergy GLI2 Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Acute myelogenous leukemia cell KG-1a Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy HISTONE H13 PS10 Downregulation Int J Oncol Rhabdomyosarcoma cell SRH Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy HISTONE H13 PS10 Upregulation Int J Oncol Rhabdomyosarcoma cell RD Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy HISTONE H13 PS10 Upregulation Int J Oncol Alveolar hrabdomyosarcomas cell RH-30 Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy HISTONE H13 PS10 Upregulation Int J Oncol Rhabdomyosarcoma cell ZF Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy PARP1 Upregulation Int J Oncol Rhabdomyosarcoma cell SRH Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy PARP1 Upregulation Int J Oncol Rhabdomyosarcoma cell RD Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy PARP1 Upregulation Int J Oncol Rhabdomyosarcoma cell CCA Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy PARP1 Upregulation Int J Oncol Alveolar hrabdomyosarcomas cell RH-30 Western blot Itraconazole 26676886 Rhabdomyosarcoma Homo sapiens synergy PARP1 Upregulation Int J Oncol Rhabdomyosarcoma cell ZF Western blot Itraconazole 27784375 Myeloma Homo sapiens synergy PATCH Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell NCI-H929 QRT-PCR,Western blot Itraconazole 28823259 Leukemia Homo sapiens synergy SMO Downregulation Zhongguo Shi Yan Xue Ye Xue Za Zhi Acute myelogenous leukemia cell KG-1a Western blot JQ1 31420604 Pancreas-cancer Homo sapiens synergy - - Oncogene Pancreatic cancer cell AsPC-1 - JQ1 31420604 Pancreas-cancer Homo sapiens synergy - - Oncogene Pancreatic cancer cell PANC-1 - JQ1 31420604 Pancreas-cancer Homo sapiens synergy - - Oncogene Pancreatic cancer cell YAPC - Knk437 19371599 Cervical-cancer Homo sapiens synergy BUBR1 Upregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot Knk437 19371599 Cervical-cancer Homo sapiens synergy CASP9 Downregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot Knk437 19371599 Cervical-cancer Homo sapiens synergy CASP9 Downregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot Knk437 19371599 Cervical-cancer Homo sapiens synergy PARP1 Upregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Flow cytometry, Western blot Knk437 19371599 Cervical-cancer Homo sapiens synergy PDS1 Upregulation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot L-ascorbic-acid 29297235 Heart-toxicity Rattus norvegicus detoxicity Bcl2 Downregulation Toxicol Mech Methods Heart myoblast H9C2 RT-PCR L-ascorbic-acid 32154163 Leukemia Homo sapiens synergy BCL2 Downregulation Front Oncol Acute promyelocytic leukemia cell HL-60 RT-PCR L-ascorbic-acid 29697268 Liver-toxicity Homo sapiens detoxicity BCL2 Downregulation Nutr Cancer Liver cell Chang liver cell RT-PCR L-ascorbic-acid 29297235 Heart-toxicity Rattus norvegicus detoxicity Nrf2 Downregulation Toxicol Mech Methods Heart myoblast H9C2 RT-PCR L-ascorbic-acid 32154163 Leukemia Homo sapiens synergy NRF2 Downregulation Front Oncol Acute promyelocytic leukemia cell HL-60 RT-PCR L-ascorbic-acid 29697268 Liver-toxicity Homo sapiens detoxicity NRF2 Downregulation Nutr Cancer Liver cell Chang liver cell RT-PCR L-ascorbic-acid 29297235 Heart-toxicity Rattus norvegicus detoxicity Ros1 Upregulation Toxicol Mech Methods Heart myoblast H9C2 Kit L-ascorbic-acid 29697268 Liver-toxicity Homo sapiens detoxicity ROS1 Upregulation Nutr Cancer Liver cell Chang liver cell Kit L-buthionine-s,r-sulfoximine 19574005 Laryngeal-cancer Homo sapiens synergy GSH Downregulation Auris Nasus Larynx Hela carcinoma cell HEP-2 Kit L-buthionine-s,r-sulfoximine 19574005 Laryngeal-cancer Homo sapiens synergy ROS1 Upregulation Auris Nasus Larynx Hela carcinoma cell HEP-2 Kit L-buthionine-sulfoximine 24838151 Laryngeal-cancer Homo sapiens synergy - - Pathol Oncol Res Hela carcinoma cell HEP-2 - Laminaria-japonica 23842700 Liver-toxicity Rattus norvegicus detoxicity - - Biol Trace Elem Res - - - Laminaria-japonica 23842700 Kidney-toxicity Rattus norvegicus detoxicity - - Biol Trace Elem Res - - - Leflunomide 27188662 Heart-toxicity Rattus norvegicus synergy Igg Downregulation Xenotransplantation - - Western blot, IHC Leflunomide 27188662 Heart-toxicity Rattus norvegicus synergy Igm Downregulation Xenotransplantation - - Western blot, IHC Lenalidomide 28927072 Myeloma Homo sapiens synergy CRBN Upregulation Oncol Lett Myeloma cell RPMI 8226 QRT-PCR Lenalidomide 28927072 Myeloma Homo sapiens synergy CRBN Upregulation Oncol Lett Myeloma cell U266 QRT-PCR, Western blot Lenalidomide 28927072 Myeloma Homo sapiens synergy IKZF1 Downregulation Oncol Lett Myeloma cell U266 Western blot Lenalidomide 28927072 Myeloma Homo sapiens synergy IKZF3 Downregulation Oncol Lett Myeloma cell U266 Western blot Lipoic-acid 17300860 Leukemia Homo sapiens detoxicity - - Food Chem Toxicol Histiocytic lymphoma cell U-937 - Lipoic-acid 17300860 Brain-cancer Homo sapiens detoxicity BAX Downregulation Food Chem Toxicol Glioblastoma cell U118 Western blot Lipoic-acid 17300860 Brain-cancer Homo sapiens detoxicity BCL2 Upregulation Food Chem Toxicol Glioblastoma cell U118 Western blot Lipoic-acid 17300860 Brain-cancer Homo sapiens detoxicity HSP70 Upregulation Food Chem Toxicol Glioblastoma cell U118 Western blot Lipoic-acid 17300860 Brain-cancer Homo sapiens detoxicity P53 Downregulation Food Chem Toxicol Glioblastoma cell U118 Western blot Lithium-chloride 28575066 Rhabdomyosarcoma Homo sapiens synergy - - PLoS One Normal skeletal muscle cell SKMC - Lithium-chloride 28575066 Rhabdomyosarcoma Homo sapiens synergy - - PLoS One Rhabdomyosarcoma cell SRH - Lithium-chloride 28575066 Rhabdomyosarcoma Homo sapiens synergy - - PLoS One Rhabdomyosarcoma cell RD - Lithium-chloride 28575066 Rhabdomyosarcoma Homo sapiens synergy - - PLoS One Alveolar hrabdomyosarcomas cell RH-30 - Lutein 26454960 Liver-toxicity Mus musculus detoxicity - - Wei Sheng Yan Jiu - - - Lutein 25815309 Liver-toxicity Mus musculus detoxicity - - Biomed Res Int - - - Lutein 26187899 Reproductive-toxicity Mus musculus detoxicity Gst Upregulation Hum Exp Toxicol - - RT-PCR Lutein 25815309 Liver-toxicity Mus musculus detoxicity HO1 Upregulation Biomed Res Int - - QRT-PCR, Western blot Lutein 26187899 Reproductive-toxicity Mus musculus detoxicity HO1 Upregulation Hum Exp Toxicol - - RT-PCR Lutein 26187899 Reproductive-toxicity Mus musculus detoxicity Nqo1 Upregulation Hum Exp Toxicol - - RT-PCR Lutein 26187899 Reproductive-toxicity Mus musculus detoxicity NRF2 Upregulation Hum Exp Toxicol - - RT-PCR Ly29004 24161621 Brain-cancer Homo sapiens synergy - - Neurochem Int Neuroblastoma cell SK-N-MC - Ly29004 24161621 Brain-cancer Homo sapiens synergy - - Neurochem Int Neuroblastoma cell SK-N-BE(2) - Ly294002 21655183 Ovary-cancer Homo sapiens synergy - - PLoS One Ovarian cancer cell A2780 - Ly294002 16115127 Leukemia Homo sapiens synergy - - Br J Haematol Acute promyelocytic leukemia cell NB4 - Ly294002 16115127 Leukemia Homo sapiens synergy - - Br J Haematol Acute lymphoblastic leukemia cell CEM - Ly294002 16115127 Leukemia Homo sapiens synergy - - Br J Haematol Leukemia cell Jurkat - Ly294002 16115127 Leukemia Homo sapiens synergy - - Br J Haematol Acute lymphoblastic leukemia cell MOLT-4 - Ly294002 26062301 Leukemia Homo sapiens synergy - - Pharmazie Acute promyelocytic leukemia cell NB4 - Ly294002 26062301 Leukemia Homo sapiens synergy - - Pharmazie Acute promyelocytic leukemia cell HL-60 - Ly294002 26062301 Leukemia Homo sapiens synergy - - Pharmazie Histiocytic lymphoma cell U-937 - Ly294002 21180886 Leukemia Rattus norvegicus synergy Akt1 Phosphorylation Braz J Med Biol Res Basophilic leukemia cell RBL-2H3 Western blot Ly294002 21655183 Ovary-cancer Homo sapiens synergy AKT1 Dephosphorylation PLoS One Ovarian cancer cell COC1 Western blot Ly294002 21655183 Ovary-cancer Homo sapiens synergy AKT1 Dephosphorylation PLoS One Ovarian cancer cell A2780 Western blot Ly294002 21655183 Ovary-cancer Homo sapiens synergy AKT1 Dephosphorylation PLoS One Ovarian cancer cell OVCAR-3 Western blot Ly294002 21180886 Leukemia Homo sapiens synergy AKT1 Phosphorylation Braz J Med Biol Res Acute promyelocytic leukemia cell HL-60 Western blot Ly294002 20137118 Leukemia Homo sapiens synergy AKT1 Upregulation,Phosphorylation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 Western blot Ly294002 23352504 Cervical-cancer Homo sapiens synergy AKT1 Phosphorylation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot Ly294002 25945059 Colorectal-cancer Homo sapiens synergy BCL2 Downregulation Onco Targets Ther Colorectal adenocarcinoma cell HT-29 QRT-PCR Ly294002 21655183 Ovary-cancer Homo sapiens synergy BIM Upregulation PLoS One Ovarian cancer cell COC1 Western blot Ly294002 21180886 Leukemia Rattus norvegicus synergy Cblb Upregulation Braz J Med Biol Res Basophilic leukemia cell RBL-2H3 Western blot Ly294002 25945059 Colorectal-cancer Homo sapiens synergy CCND1 Downregulation Onco Targets Ther Colorectal adenocarcinoma cell HT-29 QRT-PCR Ly294002 25945059 Colorectal-cancer Homo sapiens synergy GLI1 Downregulation Onco Targets Ther Colorectal adenocarcinoma cell HT-29 QRT-PCR, Western blot Ly294002 25945059 Colorectal-cancer Homo sapiens synergy GLI2 Downregulation Onco Targets Ther Colorectal adenocarcinoma cell HT-29 QRT-PCR Ly294002 23352504 Cervical-cancer Homo sapiens synergy GSK3 Phosphorylation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot Ly294002 21655183 Ovary-cancer Homo sapiens synergy JNK Phosphorylation PLoS One Ovarian cancer cell COC1 Western blot Ly294002 21655183 Ovary-cancer Homo sapiens synergy JUN Phosphorylation PLoS One Ovarian cancer cell COC1 Western blot Ly294002 20137118 Leukemia Homo sapiens synergy MTOR Upregulation,Phosphorylation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 Western blot Ly294002 20137118 Leukemia Homo sapiens synergy RPS6KB1 Upregulation,Phosphorylation Zhongguo Shi Yan Xue Ye Xue Za Zhi Chronic myelogenous leukemia cell K-562 Western blot Ly294002 23352504 Cervical-cancer Homo sapiens synergy S6K Phosphorylation Toxicol Appl Pharmacol Cervical adenocarcinoma cell HeLa-S3 Western blot Marine-algae 23842700 Liver-toxicity Rattus norvegicus detoxicity - - Biol Trace Elem Res - - - Marine-algae 23842700 Kidney-toxicity Rattus norvegicus detoxicity - - Biol Trace Elem Res - - - Matrine 23103450 Heart-toxicity Homo sapiens detoxicity - - Biochem Pharmacol Embryonic kidney cell HEK-293 - Matrine 23700110 Myeloma Homo sapiens synergy AKT1 Dephosphorylation Planta Med Myeloma cell RPMI 8226 Western blot Matrine 23700110 Myeloma Homo sapiens synergy AKT1 Dephosphorylation Planta Med Myeloma cell U266 Western blot Matrine 23700110 Myeloma Homo sapiens synergy BCL2 Downregulation Planta Med Myeloma cell RPMI 8226 Western blot Matrine 23700110 Myeloma Homo sapiens synergy BCL2 Downregulation Planta Med Myeloma cell U266 Western blot Matrine 23103450 Heart-toxicity Homo sapiens detoxicity HERG Downregulation Biochem Pharmacol Embryonic kidney cell HEK-293 Western blot Matrine 23103450 Heart-toxicity Homo sapiens detoxicity SP1 Downregulation Biochem Pharmacol Embryonic kidney cell HEK-293 Western blot Matrine 23700110 Myeloma Homo sapiens synergy SURVIVIN Downregulation Planta Med Myeloma cell RPMI 8226 Western blot Matrine 23700110 Myeloma Homo sapiens synergy SURVIVIN Downregulation Planta Med Myeloma cell U266 Western blot Megestrol-acetate 29581752 Liver-cancer Homo sapiens synergy - - Exp Ther Med Hepatocellular carcinoma cell HEPG2 - Megestrol-acetate 29581752 Liver-cancer Homo sapiens synergy - - Exp Ther Med Liver cancer cell BEL-7402 - Megestrol-acetate 29581752 Liver-cancer Homo sapiens synergy ERK1 Upregulation,Phosphorylation Exp Ther Med Hepatocellular carcinoma cell HEPG2 Western blot Megestrol-acetate 29581752 Liver-cancer Homo sapiens synergy MAPK8 Upregulation,Phosphorylation Exp Ther Med Liver cancer cell BEL-7402 Western blot Megestrol-acetate 29581752 Liver-cancer Homo sapiens synergy P38 MAPK Upregulation,Phosphorylation Exp Ther Med Liver cancer cell BEL-7402 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy - - Mol Cell Endocrinol Breast cancer cell SK-BR-3 - Melatonin 26607805 Breast-cancer Homo sapiens synergy - - Mol Cell Endocrinol Breast cancer cell MDA-MB-231 - Melatonin 27980225 Liver-toxicity Rattus norvegicus detoxicity Akt1 Dephosphorylation Oncotarget - - Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy AKT1 Dephosphorylation Mol Cell Endocrinol Breast cancer cell SK-BR-3 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy AKT1 Dephosphorylation Mol Cell Endocrinol Breast cancer cell MDA-MB-231 Western blot Melatonin 27427852 Breast-cancer Homo sapiens synergy BAX Upregulation Biomed Pharmacother Breast cancer cell MCF7 QRT-PCR Melatonin 27427852 Breast-cancer Homo sapiens synergy BCL2 Downregulation Biomed Pharmacother Breast cancer cell MCF7 QRT-PCR Melatonin 26607805 Breast-cancer Homo sapiens synergy BCL2 Downregulation Mol Cell Endocrinol Breast cancer cell SK-BR-3 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy BCL2 Downregulation Mol Cell Endocrinol Breast cancer cell MDA-MB-231 Western blot Melatonin 27980225 Liver-toxicity Rattus norvegicus detoxicity HO1 Upregulation Oncotarget - - Western blot Melatonin 27427852 Breast-cancer Homo sapiens synergy HTERT Downregulation Biomed Pharmacother Breast cancer cell MCF7 QRT-PCR Melatonin 26607805 Breast-cancer Homo sapiens synergy JNK Phosphorylation Mol Cell Endocrinol Breast cancer cell MDA-MB-231 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy MEK Dephosphorylation Mol Cell Endocrinol Breast cancer cell SK-BR-3 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy MEK Dephosphorylation Mol Cell Endocrinol Breast cancer cell MDA-MB-231 Western blot Melatonin 27980225 Liver-toxicity Rattus norvegicus detoxicity NRF2 Upregulation Oncotarget - - Western blot Melatonin 27427852 Breast-cancer Homo sapiens synergy P21 Upregulation Biomed Pharmacother Breast cancer cell MCF7 QRT-PCR Melatonin 26607805 Breast-cancer Homo sapiens synergy P38 MAPK Phosphorylation Mol Cell Endocrinol Breast cancer cell SK-BR-3 Western blot Melatonin 27427852 Breast-cancer Homo sapiens synergy P53 Upregulation Biomed Pharmacother Breast cancer cell MCF7 QRT-PCR Melatonin 26607805 Breast-cancer Homo sapiens synergy PARP1 Upregulation Mol Cell Endocrinol Breast cancer cell SK-BR-3 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy PARP1 Upregulation Mol Cell Endocrinol Breast cancer cell MDA-MB-231 Western blot Melatonin 27980225 Liver-toxicity Rattus norvegicus detoxicity Pi3k Dephosphorylation Oncotarget - - Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy S6K Dephosphorylation Mol Cell Endocrinol Breast cancer cell SK-BR-3 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy S6K Dephosphorylation Mol Cell Endocrinol Breast cancer cell MDA-MB-231 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy SURVIVIN Downregulation Mol Cell Endocrinol Breast cancer cell SK-BR-3 Western blot Melatonin 26607805 Breast-cancer Homo sapiens synergy SURVIVIN Downregulation Mol Cell Endocrinol Breast cancer cell MDA-MB-231 Western blot Melphalan 17587338 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell RPMI 8226 - Melphalan 17587338 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell U266 - Meso-2,3-di(acetylthio)succinic-acid 7506906 Liver-toxicity Mus musculus detoxicity - - Arch Toxicol - - - Meso-2,3-di(benzoylthio)succinic-acid 7506906 Liver-toxicity Mus musculus detoxicity - - Arch Toxicol - - - Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity - - Toxicol Lett - - - Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Casp12 Upregulation Toxicol Lett Heart myoblast H9C2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Casp12 Upregulation Toxicol Lett Myoblast cell H9c2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Casp3 Upregulation Toxicol Lett Heart myoblast H9C2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Casp3 Upregulation Toxicol Lett Myoblast cell H9c2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Chop Upregulation Toxicol Lett Heart myoblast H9C2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Chop Upregulation Toxicol Lett Myoblast cell H9c2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Erk1 Phosphorylation Toxicol Lett Heart myoblast H9C2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity Jnk Phosphorylation Toxicol Lett Heart myoblast H9C2 Western blot Metallothionein 23664956 Heart-toxicity Rattus norvegicus detoxicity P38 MAPK Phosphorylation Toxicol Lett Heart myoblast H9C2 Western blot Metallothionein 23664956 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Downregulation,Dephosphorylation Cancer Lett Fibrosarcoma cell HT1080 Western blot MG132 25449439 Bone-cancer Homo sapiens synergy P38 MAPK Phosphorylation,Downregulation Cancer Lett Osteosarcoma cell HOS Western blot MG132 25449439 Bone-cancer Homo sapiens synergy P38 MAPK Phosphorylation,Downregulation Cancer Lett Fibrosarcoma cell HT1080 Western blot Mkc-3946 26934650 Leukemia Homo sapiens synergy - - Oncotarget Leukemic stem cell LSCS - Mkc-3946 26934650 Leukemia Homo sapiens synergy - - Oncotarget Leukemic stem cell HSCS - ML-7 32683294 Lung-toxicity Homo sapiens detoxicity OCLN Downregulation Toxicol Lett Normal lung epithelial cell BEAS-2B Western blot Monoterpene-eugenol 28494415 Heart-toxicity Rattus norvegicus detoxicity - - Biomed Pharmacother - - - Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Bax Upregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Bcl2 Downregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Bclxll Downregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Casp3 Upregulation Biol Trace Elem Res Heart myoblast H9C2 Kit Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Clap1 Downregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Clap2 Downregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Nfkb Downregulation Biol Trace Elem Res Heart myoblast H9C2 ELISA Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Puma Upregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Ros1 Upregulation Biol Trace Elem Res Heart myoblast H9C2 Kit Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Survivin Downregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR Morphine 26815588 Heart-toxicity Rattus norvegicus detoxicity Xiap Downregulation Biol Trace Elem Res Heart myoblast H9C2 QRT-PCR N-(beta-elemene-13-yl)tryptophan-methyl-ester 26579413 Liver-cancer Homo sapiens synergy - - Acta Pharm Sin B Hepatocellular carcinoma cell SMMC-7721 - N-(beta-elemene-13-yl)tryptophan-methyl-ester 26579413 Liver-cancer Homo sapiens synergy BAX Upregulation Acta Pharm Sin B Hepatocellular carcinoma cell SMMC-7721 Western blot N-(beta-elemene-13-yl)tryptophan-methyl-ester 26579413 Liver-cancer Homo sapiens synergy BCL2 Upregulation Acta Pharm Sin B Hepatocellular carcinoma cell SMMC-7721 Western blot N-(beta-elemene-13-yl)tryptophan-methyl-ester 26579413 Liver-cancer Homo sapiens synergy CCNB1 Upregulation Acta Pharm Sin B Hepatocellular carcinoma cell SMMC-7721 Western blot N-(beta-elemene-13-yl)tryptophan-methyl-ester 26579413 Liver-cancer Homo sapiens synergy CCND1 Upregulation Acta Pharm Sin B Hepatocellular carcinoma cell SMMC-7721 Western blot N-acetylcysteine 18418892 Leukemia Homo sapiens synergy - - J Biochem Mol Toxicol Acute promyelocytic leukemia cell HL-60 - N-acetylcysteine 26839632 Reproductive-toxicity Mus musculus detoxicity - - Oxid Med Cell Longev - - - N-acetylcysteine 26839632 Reproductive-toxicity Mus musculus detoxicity - - Oxid Med Cell Longev - - - N-acetylcysteine 26839632 Reproductive-toxicity Mus musculus detoxicity - - Oxid Med Cell Longev - - - N-acetylcysteine 26839632 Reproductive-toxicity Mus musculus detoxicity - - Oxid Med Cell Longev - - - N-acetylcysteine 26839632 Reproductive-toxicity Mus musculus detoxicity - - Oxid Med Cell Longev - - - N-acetylcysteine 26839632 Reproductive-toxicity Mus musculus detoxicity - - Oxid Med Cell Longev - - - N-acetylcysteine 25906049 Genotoxicity Mus musculus detoxicity - - Toxicol Mech Methods Bone marrow cell Mouse bone marrow cell - N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Atf4 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Chop Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Eif2a Phosphorylation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 Western blot N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Erk1 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot N-acetylcysteine 32683294 Lung-toxicity Homo sapiens detoxicity ERK1 Phosphorylation Toxicol Lett Normal lung epithelial cell BEAS-2B Western blot N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Grp78 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Grp94 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR, Western blot N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Hrd1 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR N-acetylcysteine 32683294 Lung-toxicity Homo sapiens detoxicity OCLN Downregulation Toxicol Lett Normal lung epithelial cell BEAS-2B QRT-PCR, Western blot N-acetylcysteine 32683294 Lung-toxicity Homo sapiens detoxicity P38 MAPK Phosphorylation Toxicol Lett Normal lung epithelial cell BEAS-2B Western blot N-acetylcysteine 23954561 Immune-toxicity Mus musculus detoxicity Xbp1 Upregulation Toxicol Appl Pharmacol Leukemia cell RAW 264.7 RT-PCR N-propylthiouracil 17697958 Liver-toxicity Rattus norvegicus detoxicity - - J Trace Elem Med Biol - - - NaF 31605998 Development-toxicity Mus musculus detoxicity - - Chemosphere - - - NaF 18187247 Ovary-toxicity Mus musculus synergy - - Food Chem Toxicol - - - NaF 31605998 Development-toxicity Mus musculus detoxicity Atg13 Upregulation Chemosphere - - QRT-PCR NaF 31605998 Development-toxicity Mus musculus detoxicity Bcl2 Downregulation Chemosphere - - QRT-PCR,Western blot NaF 31605998 Development-toxicity Mus musculus detoxicity Becn1 Upregulation Chemosphere - - QRT-PCR,Western blot NaF 31605998 Development-toxicity Mus musculus detoxicity Map1lc3a Downregulation Chemosphere - - IFA NaF 31605998 Development-toxicity Mus musculus detoxicity Map1lc3a Upregulation Chemosphere - - Western blot NaF 31605998 Development-toxicity Mus musculus detoxicity Mtor Downregulation Chemosphere - - QRT-PCR,Western blot NaF 31605998 Development-toxicity Mus musculus detoxicity Ulk1 Upregulation Chemosphere - - QRT-PCR Naringenin 25272058 Liver-toxicity Mus musculus detoxicity - - J Environ Pathol Toxicol Oncol - - - Naringenin 25272058 Kidney-toxicity Mus musculus detoxicity - - J Environ Pathol Toxicol Oncol - - - Nutlin-3 24884809 Liver-cancer Homo sapiens synergy - - Mol Cancer Hepatocellular carcinoma cell HEPG2 - Nutlin-3 24884809 Liver-cancer Homo sapiens synergy - - Mol Cancer Liver cancer cell Huh7 - Nutlin-3 24884809 Liver-cancer Homo sapiens synergy - - Mol Cancer Hepatocellular carcinoma cell HEP3B - Nutlin-3 24884809 Liver-cancer Homo sapiens synergy - - Mol Cancer Hepatocellular carcinoma cell SMMC-7721 - Nutlin-3 24884809 Liver-cancer Homo sapiens synergy BAX Upregulation Mol Cancer Hepatocellular carcinoma cell HEPG2 Western blot Nutlin-3 24884809 Liver-cancer Homo sapiens synergy BAX Upregulation Mol Cancer Hepatocellular carcinoma cell SMMC-7721 Western blot Nutlin-3 24884809 Liver-cancer Homo sapiens synergy NOXA Upregulation Mol Cancer Hepatocellular carcinoma cell HEPG2 Western blot Nutlin-3 24884809 Liver-cancer Homo sapiens synergy NOXA Upregulation Mol Cancer Hepatocellular carcinoma cell SMMC-7721 Western blot Nutlin-3 24884809 Liver-cancer Homo sapiens synergy PUMA Upregulation Mol Cancer Hepatocellular carcinoma cell HEPG2 Western blot Nutlin-3 24884809 Liver-cancer Homo sapiens synergy PUMA Upregulation Mol Cancer Hepatocellular carcinoma cell SMMC-7721 Western blot Omega-3-fatty-acid 23081861 Liver-toxicity Rattus norvegicus detoxicity - - Toxicol Ind Health - - - Omega-3-fatty-acid 26886836 Heart-toxicity Rattus norvegicus detoxicity - - Cardiovasc Toxicol Heart myoblast H9C2 - Oridonin 21947421 Liver-cancer Homo sapiens synergy - - Int J Oncol Hepatocellular carcinoma cell SMMC-7721 - Oridonin 21947421 Liver-cancer Homo sapiens synergy - - Int J Oncol Hepatocellular carcinoma cell HEPG2 - Oridonin 21947421 Liver-cancer Mus musculus synergy - - Int J Oncol Hepatoma cell HEPA1-6 - Oridonin 21947421 Liver-cancer Homo sapiens synergy AKT1 Downregulation Int J Oncol Liver cancer cell BEL-7402 Western blot Oridonin 21947421 Liver-cancer Homo sapiens synergy BAX Downregulation Int J Oncol Liver cancer cell BEL-7402 Western blot Oridonin 21947421 Liver-cancer Homo sapiens synergy CASP3 Upregulation Int J Oncol Liver cancer cell BEL-7402 Western blot Oridonin 21947421 Liver-cancer Homo sapiens synergy CASP9 Downregulation Int J Oncol Liver cancer cell BEL-7402 Western blot Oridonin 21947421 Liver-cancer Homo sapiens synergy ERK1 Phosphorylation Int J Oncol Liver cancer cell BEL-7402 Western blot Oridonin 21947421 Liver-cancer Homo sapiens synergy MAPK8 Phosphorylation Int J Oncol Liver cancer cell BEL-7402 Western blot Oridonin 21947421 Liver-cancer Homo sapiens synergy PARP1 Upregulation Int J Oncol Liver cancer cell BEL-7402 Western blot Oridonin 21947421 Liver-cancer Homo sapiens synergy XIAP Downregulation Int J Oncol Liver cancer cell BEL-7402 Western blot Oxymatrine 23103450 Heart-toxicity Homo sapiens detoxicity - - Biochem Pharmacol Embryonic kidney cell HEK-293 - Oxymatrine 23103450 Heart-toxicity Homo sapiens detoxicity HERG Downregulation Biochem Pharmacol Embryonic kidney cell HEK-293 Western blot Oxymatrine 27713174 Liver-toxicity Rattus norvegicus detoxicity HO1 Upregulation Oncotarget - - Western blot Oxymatrine 27713174 Liver-toxicity Rattus norvegicus detoxicity NRF2 Upregulation Oncotarget - - Western blot Oxymatrine 27713174 Liver-toxicity Rattus norvegicus detoxicity Ros1 Upregulation Oncotarget - - Kit Oxymatrine 23103450 Heart-toxicity Homo sapiens detoxicity SP1 Downregulation Biochem Pharmacol Embryonic kidney cell HEK-293 Western blot Paclitaxel 19781537 Leukemia Homo sapiens synergy - - Chem Biol Interact Leukemia cell Jurkat - Paclitaxel 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Lung adenocarcinoma cell A549 - Paclitaxel 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Colon adenocarcinoma cell LoVo - Paclitaxel 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Breast cancer cell MCF7 - Paclitaxel 26884726 Lung-cancer Homo sapiens synergy - - Cancer Cell Int Lung cancer cell NCI-H1299 - Paclitaxel 14726646 Myeloma Homo sapiens synergy - - Cell Cycle Myeloma cell U266 - Paclitaxel 14726646 Myeloma Homo sapiens synergy - - Cell Cycle Myeloma cell RPMI 8226 - Paclitaxel 19781537 Leukemia Homo sapiens synergy BUBR1 Upregulation,Phosphorylation Chem Biol Interact Leukemia cell Jurkat Western blot Paclitaxel 19781537 Leukemia Homo sapiens synergy CDC25C Upregulation,Phosphorylation Chem Biol Interact Leukemia cell Jurkat Western blot Paclitaxel 19781537 Leukemia Homo sapiens synergy CDK1 Upregulation,Phosphorylation Chem Biol Interact Leukemia cell Jurkat Western blot Paclitaxel 19781537 Leukemia Homo sapiens synergy HISTONE H3 Upregulation Chem Biol Interact Leukemia cell Jurkat Western blot, IFA Paclitaxel 26225652 Breast-cancer Homo sapiens synergy PPM1D Downregulation Asian Pac J Cancer Prev Breast cancer cell MCF7 QRT-PCR Paclitaxel 26225652 Breast-cancer Homo sapiens synergy TP53 Upregulation Asian Pac J Cancer Prev Breast cancer cell MCF7 QRT-PCR Panobinostat 25628765 Leukemia Homo sapiens synergy - - Clin Epigenetics Leukemia cell A/E9A;NRAS G12D - Panobinostat 25628765 Leukemia Homo sapiens synergy ACH3 Downregulation Clin Epigenetics Leukemia cell A/E9A;NRAS G12D Western blot Panobinostat 25628765 Leukemia Homo sapiens synergy PML Downregulation Clin Epigenetics Leukemia cell A/E9A;NRAS G12D Western blot Parthenolide 19342982 Pancreas-cancer Homo sapiens synergy - - Pancreas Normal lymphocyte Normal lymphocyte - Parthenolide 19342982 Pancreas-cancer Homo sapiens synergy Cytochrome c Upregulation Pancreas Pancreatic cancer cell PANC-1 Western blot Parthenolide 19342982 Pancreas-cancer Homo sapiens synergy Cytochrome c Upregulation Pancreas Pancreatic cancer cell BXPC-3 Western blot Parthenolide 19342982 Pancreas-cancer Homo sapiens synergy HO1 Upregulation Pancreas Pancreatic cancer cell PANC-1 Western blot Parthenolide 19342982 Pancreas-cancer Homo sapiens synergy HO1 Upregulation Pancreas Pancreatic cancer cell BXPC-3 Western blot Pd173074 27794399 Lung-cancer Homo sapiens synergy - - Lung Cancer Lung cancer cell SK-MES-1 - Pd173074 27794399 Lung-cancer Homo sapiens synergy AKT1 Downregulation,Dephosphorylation Lung Cancer Lung cancer cell SK-MES-1 Western blot Pd173074 27794399 Lung-cancer Homo sapiens synergy ERK1 Phosphorylation,Downregulation Lung Cancer Lung cancer cell SK-MES-1 Western blot Pd173074 27794399 Lung-cancer Homo sapiens synergy FGFR1 Downregulation Lung Cancer Lung cancer cell SK-MES-1 Western blot Pd173074 27794399 Lung-cancer Homo sapiens synergy RAF Dephosphorylation Lung Cancer Lung cancer cell SK-MES-1 Western blot Pd173074 27794399 Lung-cancer Homo sapiens synergy SRC Downregulation,Dephosphorylation Lung Cancer Lung cancer cell SK-MES-1 Western blot Pd173074 27794399 Lung-cancer Homo sapiens synergy SURVIVIN Upregulation Lung Cancer Lung cancer cell SK-MES-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy - - Blood Myeloma cell XG-1 - Pd184352 18583568 Myeloma Homo sapiens synergy - - Blood B-lymphocyte B lymphocytes - Pd184352 18583568 Myeloma Homo sapiens synergy - - Blood Bone marrow mononuclear cell BMMCs - Pd184352 16467208 Leukemia Homo sapiens synergy BAD Phosphorylation Blood Acute myelogenous leukemia cell AML blasts Western blot Pd184352 18583568 Myeloma Homo sapiens synergy BAX Upregulation Blood Myeloma cell XG-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy BAX Downregulation Blood Myeloma cell OPM2 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy BAX Upregulation Blood Myeloma cell XG-6 Western blot Pd184352 16467208 Leukemia Homo sapiens synergy BAX Upregulation Blood Acute myelogenous leukemia cell AML blasts Western blot Pd184352 18583568 Myeloma Homo sapiens synergy BID Downregulation Blood Myeloma cell RPMI 8226 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy BID Downregulation Blood Myeloma cell JJN3 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP3 Upregulation Blood Myeloma cell XG-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP3 Upregulation Blood Myeloma cell RPMI 8226 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP3 Upregulation Blood Primary multiple myeloma cell Primary multiple myeloma cell Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP8 Downregulation Blood Myeloma cell XG-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP8 Downregulation Blood Myeloma cell RPMI 8226 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP8 Upregulation Blood Myeloma cell JJN3 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP9 Upregulation Blood Myeloma cell XG-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP9 Upregulation Blood Myeloma cell RPMI 8226 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP9 Upregulation Blood Myeloma cell JJN3 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy CASP9 Upregulation Blood Primary multiple myeloma cell Primary multiple myeloma cell Western blot Pd184352 18583568 Myeloma Homo sapiens synergy DR4 Upregulation Blood Myeloma cell JJN3 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy P53 Upregulation Blood Myeloma cell XG-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy P53 Upregulation Blood Myeloma cell RPMI 8226 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy PARP Upregulation Blood Primary multiple myeloma cell Primary multiple myeloma cell Western blot Pd184352 18583568 Myeloma Homo sapiens synergy PARP1 Upregulation Blood Myeloma cell XG-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy PARP1 Upregulation Blood Myeloma cell RPMI 8226 Western blot Pd184352 16467208 Leukemia Homo sapiens synergy PARP1 Upregulation Blood Acute myelogenous leukemia cell AML blasts Western blot Pd184352 18583568 Myeloma Homo sapiens synergy PUMA Upregulation Blood Myeloma cell XG-1 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy PUMA Upregulation Blood Myeloma cell OPM2 Western blot Pd184352 18583568 Myeloma Homo sapiens synergy PUMA Upregulation Blood Myeloma cell XG-6 Western blot Pd184352 16467208 Leukemia Homo sapiens synergy PUMA Upregulation Blood Acute myelogenous leukemia cell AML blasts Western blot Pd98059 16972261 Leukemia Homo sapiens synergy - - J Cell Physiol Acute promyelocytic leukemia cell NB4 - Pd98059 16972261 Leukemia Homo sapiens synergy - - J Cell Physiol Histiocytic lymphoma cell U-937 - Pd98059 25983101 Esophageal-cancer Homo sapiens synergy ANXA1 Upregulation Tumori Esophageal squamous carcinoma cell ECA109 RT-PCR,QRT-PCR Pd98059 25983101 Gastric-cancer Homo sapiens synergy ANXA1 Upregulation Tumori Gastric adenocarcinoma cell SGC-7901 RT-PCR,QRT-PCR, Western blot Pd98059 25983101 Pancreas-cancer Homo sapiens synergy ANXA1 Upregulation Tumori Pancreatic cancer cell BxPC-3 RT-PCR,QRT-PCR, Western blot Pd98059 25983101 Colorectal-cancer Homo sapiens synergy ANXA1 Upregulation Tumori Colorectal cancer cell LS 174 RT-PCR,QRT-PCR, Western blot Pd98059 15538402 Leukemia Homo sapiens synergy BAX Upregulation Leukemia Acute promyelocytic leukemia cell NB4 Western blot Pd98059 15538402 Leukemia Homo sapiens synergy BCL-XL Upregulation Leukemia Acute promyelocytic leukemia cell NB4 Western blot Pd98059 32683294 Lung-toxicity Homo sapiens detoxicity ELK1 Phosphorylation Toxicol Lett Normal lung epithelial cell BEAS-2B Western blot Pd98059 16445569 Breast-cancer Homo sapiens synergy ERK1 Phosphorylation,Downregulation Clin Exp Pharmacol Physiol Breast cancer cell MCF7 Western blot Pd98059 15538402 Leukemia Homo sapiens synergy ERK1 Phosphorylation Leukemia Acute promyelocytic leukemia cell NB4 Western blot Pd98059 19846917 Lung-cancer Homo sapiens - GSH Upregulation Anticancer Res Lung cancer cell CALU-6 Kit Pd98059 25983101 Esophageal-cancer Homo sapiens synergy LMNA Upregulation Tumori Esophageal squamous carcinoma cell ECA109 RT-PCR,QRT-PCR, Western blot Pd98059 25983101 Gastric-cancer Homo sapiens synergy LMNA Upregulation Tumori Gastric adenocarcinoma cell SGC-7901 RT-PCR,QRT-PCR, Western blot Pd98059 25983101 Pancreas-cancer Homo sapiens synergy LMNA Upregulation Tumori Pancreatic cancer cell BxPC-3 RT-PCR,QRT-PCR, Western blot Pd98059 25983101 Colorectal-cancer Homo sapiens synergy LMNA Upregulation Tumori Colorectal cancer cell LS 174 RT-PCR,QRT-PCR, Western blot Pd98059 32683294 Lung-toxicity Homo sapiens detoxicity MLCK Upregulation Toxicol Lett Normal lung epithelial cell BEAS-2B QRT-PCR Pd98059 32683294 Lung-toxicity Homo sapiens detoxicity OCLN Downregulation Toxicol Lett Normal lung epithelial cell BEAS-2B QRT-PCR, Western blot Pd98059 16445569 Breast-cancer Homo sapiens synergy P38 MAPK Phosphorylation Clin Exp Pharmacol Physiol Breast cancer cell MCF7 Western blot Pd98059 15538402 Leukemia Homo sapiens synergy PARP1 Upregulation Leukemia Acute promyelocytic leukemia cell NB4 Western blot Pft-alpha 17487067 Liver-cancer Homo sapiens detoxicity P53 Downregulation Biomed Sci Instrum Hepatocellular carcinoma cell HEPG2 Western blot Pft-alpha 17487067 Liver-toxicity Rattus norvegicus detoxicity P53 Downregulation Biomed Sci Instrum Liver cell Rat liver cell Western blot Pft-alpha 17487067 Liver-cancer Homo sapiens detoxicity PCNA Upregulation Biomed Sci Instrum Hepatocellular carcinoma cell HEPG2 Western blot Phenylarsine-oxide 15291359 Leukemia Homo sapiens synergy BCL-XL Upregulation Leuk Lymphoma Acute promyelocytic leukemia cell NB4 Western blot Phenylarsine-oxide 15291359 Leukemia Homo sapiens synergy BCL2 Downregulation Leuk Lymphoma Acute promyelocytic leukemia cell NB4 Western blot Phloretin 25746422 Heart-toxicity Rattus norvegicus detoxicity Casp3 Upregulation Eur J Pharmacol Heart myoblast H9C2 Kit Phloretin 25746422 Heart-toxicity Rattus norvegicus detoxicity Nrf2 Upregulation Eur J Pharmacol Heart myoblast H9C2 Kit Phytosphingosine 17237268 Leukemia Homo sapiens synergy - - Mol Cancer Ther Histiocytic lymphoma cell U-937 - Phytosphingosine 17237268 Myeloma Homo sapiens synergy - - Mol Cancer Ther Multiple myeloma cell IM-9 - Phytosphingosine 17237268 Leukemia Homo sapiens synergy - - Mol Cancer Ther Chronic myelogenous leukemia cell K-562 - Phytosphingosine 17237268 Myeloma Homo sapiens synergy - - Mol Cancer Ther Myeloma cell U266 - Phytosphingosine 17237268 Leukemia Homo sapiens synergy BAX Downregulation Mol Cancer Ther Histiocytic lymphoma cell U-937 Western blot Phytosphingosine 17237268 Leukemia Homo sapiens synergy HSP60 Downregulation Mol Cancer Ther Histiocytic lymphoma cell U-937 Western blot Phytosphingosine 17237268 Leukemia Homo sapiens synergy JNK Dephosphorylation Mol Cancer Ther Histiocytic lymphoma cell U-937 Western blot Phytosphingosine 17237268 Leukemia Homo sapiens synergy P38 MAPK Phosphorylation Mol Cancer Ther Histiocytic lymphoma cell U-937 Western blot Piceatannol 19925860 Blood-toxicity Homo sapiens detoxicity SKY Upregulation,Phosphorylation Toxicol In Vitro Neutrophil cell Neutrophil Western blot Polyphyllin-i 26821882 Myeloma Homo sapiens synergy - - Eur J Haematol Myeloma cell U266 - Polyphyllin-i 26821882 Myeloma Homo sapiens synergy - - Eur J Haematol Myeloma cell RPMI 8226 - Polyphyllin-i 26821882 Myeloma Homo sapiens synergy - - Eur J Haematol Normal haematopoietic cell Normal hamatopoietic - Porphyra-haitanensis 23842700 Liver-toxicity Rattus norvegicus detoxicity - - Biol Trace Elem Res - - - Porphyra-haitanensis 23842700 Kidney-toxicity Rattus norvegicus detoxicity - - Biol Trace Elem Res - - - PP2 24953245 Leukemia Homo sapiens synergy - - Leuk Res Acute promyelocytic leukemia cell NB4 - PP2 23864846 Leukemia Homo sapiens synergy Ctsd Downregulation Cancer Res Treat Acute promyelocytic leukemia cell NB4 Western blot Proanthocyanidins 31355259 Liver-toxicity Homo sapiens detoxicity AS3MT Upregulation Biomed Res Int Embryo hepatocyte L-O2 ELISA Proanthocyanidins 31355259 Liver-toxicity Homo sapiens detoxicity GSH Downregulation Biomed Res Int Embryo hepatocyte L-O2 ELISA Proanthocyanidins 31355259 Liver-toxicity Homo sapiens detoxicity MRP1 Downregulation Biomed Res Int Embryo hepatocyte L-O2 ELISA Pure-total-flavonoid-compounds 26160715 Leukemia Homo sapiens synergy - - J Zhejiang Univ Sci B Acute myeloid leukemia cell Kasumi-1 - Pure-total-flavonoid-compounds 26160715 Leukemia Homo sapiens synergy P65 Downregulation J Zhejiang Univ Sci B Acute myeloid leukemia cell Kasumi-1 Western blot Pure-total-flavonoid-compounds 26160715 Leukemia Homo sapiens synergy PARP1 Upregulation J Zhejiang Univ Sci B Acute myeloid leukemia cell Kasumi-1 Western blot PX-12 25197347 Leukemia Homo sapiens synergy - - Int J Clin Exp Pathol Acute promyelocytic leukemia cell HL-60 - PX-12 25197347 Leukemia Homo sapiens synergy - - Int J Clin Exp Pathol Histiocytic lymphoma cell U-937 - PX-12 25197347 Leukemia Homo sapiens synergy - - Int J Clin Exp Pathol Acute myeloid leukemia cell Primary AML cell - PX-12 25197347 Leukemia Homo sapiens synergy TRX1 Downregulation Int J Clin Exp Pathol Acute promyelocytic leukemia cell NB4 Western blot Px-478 27212442 Pancreas-cancer Homo sapiens synergy CASP3 Upregulation Cancer Lett Pancreatic cancer cell PANC-1 IHC 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AKT1 Phosphorylation Biochem Pharmacol Acute promyelocytic leukemia cell NB4 Western blot Quercetin 18359480 Leukemia Homo sapiens synergy BCL-XL Upregulation Biochem Pharmacol Histiocytic lymphoma cell U-937 Western blot Quercetin 18359480 Leukemia Homo sapiens synergy BCL2 Upregulation Biochem Pharmacol Histiocytic lymphoma cell U-937 Western blot Quercetin 18359480 Leukemia Homo sapiens synergy BID Upregulation Biochem Pharmacol Histiocytic lymphoma cell U-937 Western blot Quercetin 18359480 Leukemia Homo sapiens synergy HSP70 Upregulation Biochem Pharmacol Histiocytic lymphoma cell U-937 Western blot Quercetin 18359480 Leukemia Homo sapiens synergy XIAP Downregulation Biochem Pharmacol Histiocytic lymphoma cell U-937 Western blot Radiation 17431388 Nasopharyngeal-cancer Homo sapiens synergy - - Exp Oncol Nasopharyngeal carcinoma cell CSNET-1 - Radiation 14689968 Brain-cancer Rattus norvegicus synergy - - Radiat Res Gliosarcoma cell 9L/lacZ - Radiation 28459147 Brain-cancer Homo 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25919768 Immune-toxicity Mus musculus synergy Ikbkb Downregulation Transplantation T cell T cell ELISA Rapamycin 25919768 Immune-toxicity Mus musculus synergy Il2 Downregulation Transplantation T cell T cell ELISA Rapamycin 25919768 Immune-toxicity Mus musculus synergy Il2 Downregulation Transplantation - - QRT-PCR Rapamycin 33352257 Liver-toxicity Mus musculus detoxicity Map1lc3a Upregulation In Vitro Normal hepatocyte AML12 QRT-PCR, Western blot Rapamycin 32044640 Reproductive-toxicity Mus musculus detoxicity Map1lc3a Upregulation J Hazard Mater Testis leydig tumor cell MLTC-1 QRT-PCR, Western blot Rapamycin 25758096 Leukemia Homo sapiens synergy MAPK Phosphorylation Int J Hematol Acute promyelocytic leukemia cell HL-60 Western blot Rapamycin 25758096 Leukemia Homo sapiens synergy MAPK Downregulation Int J Hematol Histiocytic lymphoma cell U-937 Western blot Rapamycin 25758096 Leukemia Homo sapiens synergy MCL1 Downregulation Int J Hematol Histiocytic lymphoma cell U-937 Western blot 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Biol Interact Lung adenocarcinoma cell A549 Western blot Resveratrol 30343279 Brain-cancer Homo sapiens synergy CASP3 Upregulation Cancer Genomics Proteomics Neuroblastoma cell SKNSH Western blot Resveratrol 25339131 Lung-toxicity Homo sapiens detoxicity CASP8 Upregulation Environ Mol Mutagen Bronchial epithelial cell HBE Kit Resveratrol 25339131 Lung-toxicity Homo sapiens detoxicity CASP9 Upregulation Environ Mol Mutagen Bronchial epithelial cell HBE Kit Resveratrol 30343279 Brain-cancer Homo sapiens synergy CASP9 Upregulation Cancer Genomics Proteomics Neuroblastoma cell SKNSH Western blot Resveratrol 26772155 Lung-cancer Homo sapiens synergy CHOP Upregulation Chem Biol Interact Lung adenocarcinoma cell A549 Western blot Resveratrol 29876539 Mammary-toxicity Homo sapiens detoxicity CYP1B1 Downregulation ACS Omega Breast epithelial cell MCF 10A Western blot Resveratrol 26987203 Lung-cancer Homo sapiens synergy Cytochrome c Upregulation Wei Sheng Yan Jiu Lung adenocarcinoma cell A549 Western blot Resveratrol 26772155 Lung-cancer Homo sapiens synergy Cytochrome c Upregulation Chem Biol Interact Lung adenocarcinoma cell A549 Western blot Resveratrol 25431299 Lung-cancer Homo sapiens synergy Cytochrome c Upregulation Biol Trace Elem Res Lung adenocarcinoma cell A549 Western blot Resveratrol 25339131 Lung-toxicity Homo sapiens detoxicity Cytochrome c Upregulation Environ Mol Mutagen Bronchial epithelial cell HBE Western blot Resveratrol 25431299 Lung-cancer Homo sapiens synergy FAS Upregulation Biol Trace Elem Res Lung adenocarcinoma cell A549 Western blot Resveratrol 25339131 Lung-toxicity Homo sapiens detoxicity FAS Upregulation Environ Mol Mutagen Bronchial epithelial cell HBE Western blot Resveratrol 25431299 Lung-cancer Homo sapiens synergy FASL Upregulation Biol Trace Elem Res Lung adenocarcinoma cell A549 Western blot Resveratrol 25339131 Lung-toxicity Homo sapiens detoxicity FASL Upregulation Environ Mol Mutagen Bronchial epithelial cell HBE Western blot Resveratrol 25339131 Lung-toxicity Homo sapiens detoxicity GCLC Downregulation Environ Mol Mutagen Bronchial epithelial cell HBE Western blot Resveratrol 25339131 Lung-toxicity Homo sapiens detoxicity GCLM Downregulation Environ Mol Mutagen Bronchial epithelial cell HBE Western blot Resveratrol 26772155 Lung-cancer Homo sapiens synergy GRP78 Upregulation Chem Biol Interact Lung adenocarcinoma cell A549 Western blot Resveratrol 24327821 Heart-toxicity Rattus norvegicus detoxicity HO1 Downregulation Evid Based Complement Alternat Med - - QRT-PCR Resveratrol 25107562 Heart-toxicity Homo sapiens detoxicity Kcnh2 Downregulation Naunyn Schmiedebergs Arch Pharmacol Embryonic kidney cell HEK-293 Western blot Resveratrol 31218953 Colorectal-cancer Homo sapiens synergy KCNH2 Downregulation Curr Pharm Des Colorectal carcinoma cell HCT116 Western blot Resveratrol 25107562 Heart-toxicity Homo sapiens detoxicity KCNH2 Downregulation Naunyn Schmiedebergs Arch Pharmacol Embryonic kidney cell HEK-293 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Biomed Res Int - - Kit Resveratrol-(rev)or 25144547 Leukemia Rattus norvegicus synergy Map1lc3a Upregulation PLoS One Neonatal left ventricular myocyte Neonatal rat left ventricular myocytes Western blot Resveratrol-(rev)or 25144547 Leukemia Homo sapiens synergy MAP1LC3A Upregulation PLoS One Acute promyelocytic leukemia cell NB4 Western blot Resveratrol-(rev)or 25144547 Leukemia Rattus norvegicus synergy Ros1 Upregulation PLoS One Neonatal left ventricular myocyte Neonatal rat left ventricular myocytes Kit Resveratrol-(rev)or 25144547 Leukemia Homo sapiens synergy ROS1 Upregulation PLoS One Acute promyelocytic leukemia cell NB4 Kit Retinoic-acid 31761398 Leukemia Homo sapiens synergy - - Int J Cardiol Erythroleukemia cell TF-1 - Retinoic-acid 31761398 Leukemia Homo sapiens synergy - - Int J Cardiol Histiocytic lymphoma cell U-937 - Retinoic-acid 31263158 Leukemia Homo sapiens synergy - - Sci Rep Acute promyelocytic leukemia cell NB4 - Retinoic-acid 28404891 Leukemia Homo sapiens synergy - - Oncotarget Endothelial cell EA.hy926 - Retinoic-acid 28276286 Leukemia Homo sapiens synergy - - Leuk Lymphoma Acute monocytic leukemia cell THP-1 - Retinoic-acid 20886602 Leukemia Mus musculus synergy - - Environ Toxicol Leukemia cell WEHI-3 - Retinoic-acid 20615082 Leukemia Homo sapiens synergy - - Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 - Retinoic-acid 19642359 Leukemia Homo sapiens synergy - - Zhonghua Xue Ye Xue Za Zhi - - - Retinoic-acid 19382468 Leukemia Homo sapiens synergy - - Zhongguo Zhong Xi Yi Jie He Za Zhi - - - Retinoic-acid 18354491 Leukemia Homo sapiens synergy - - Leukemia Acute promyelocytic leukemia cell NB4 - Retinoic-acid 17825229 Leukemia Homo sapiens synergy - - Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi Histiocytic lymphoma cell U-937 - Retinoic-acid 17706770 Leukemia Homo sapiens synergy - - Leuk Res Acute promyelocytic leukemia cell HL-60 - Retinoic-acid 17550847 Leukemia Homo sapiens synergy - - Haematologica Lymphoma cell HuT 102 - 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QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy ATF5 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR, Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy ATF5 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR, Western blot Retinoic-acid 26892147 Leukemia Homo sapiens synergy AZU1 Downregulation Life Sci Acute promyelocytic leukemia cell HL-60 QRT-PCR Retinoic-acid 9596679 Leukemia Homo sapiens synergy BCL2 Downregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 9596679 Leukemia Homo sapiens synergy BCL2 Downregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 31263158 Leukemia Homo sapiens synergy CCL2 Upregulation Sci Rep Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 19828696 Leukemia Homo sapiens synergy CCL2 Upregulation Blood Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 19828696 Leukemia Homo sapiens synergy CCL7 Upregulation Blood Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 18055984 Leukemia Homo sapiens synergy CD18 Downregulation Haematologica Acute promyelocytic leukemia cell NB4 IFA Retinoic-acid 28276286 Leukemia Homo sapiens synergy CHEK1 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy CHEK1 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Retinoic-acid 17706770 Leukemia Homo sapiens synergy CYCE Downregulation Leuk Res Acute promyelocytic leukemia cell HL-60 Western blot Retinoic-acid 18491231 Leukemia Homo sapiens synergy DAP5 Upregulation Apoptosis Acute promyelocytic leukemia cell NB4 RT-PCR, Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy E2F1 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR, Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy E2F1 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR, Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy EGFl7 Downregulation Leuk Lymphoma Acute monocytic leukemia cell THP-1 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy EGFl7 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy EGFl7 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy ERK1 Downregulation Tumour Biol Glioblastoma cell U-87 MG IFA Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy ERK1 Upregulation Tumour Biol Likely glioblastoma cell U-87 MG IFA Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy ERK1 Downregulation Tumour Biol Likely glioblastoma cell U-87 MG IFA Retinoic-acid 28276286 Leukemia Homo sapiens synergy ERK1 Dephosphorylation Leuk Lymphoma Acute monocytic leukemia cell THP-1 Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy ERK1 Dephosphorylation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 Western blot Retinoic-acid 20615082 Leukemia Homo sapiens synergy ERK1 Phosphorylation Leuk Lymphoma Acute promyelocytic leukemia cell HL-60 Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy FERRITIN Upregulation Br J Cancer Acute promyelocytic leukemia cell HL-60 RT-PCR Retinoic-acid 25003661 Leukemia Homo sapiens synergy FERRITIN Upregulation Br J Cancer Acute monocytic leukemia cell THP-1 RT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy FLT3 Downregulation Leuk Lymphoma Acute monocytic leukemia cell THP-1 Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy FLT3 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy FLT3 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 Western blot Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy GFAP Downregulation Tumour Biol Glioblastoma cell U-87 MG IFA Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy GFAP Downregulation Tumour Biol Likely glioblastoma cell U-87 MG IFA Retinoic-acid 28276286 Leukemia Homo sapiens synergy GINS2 Downregulation Leuk Lymphoma Acute monocytic leukemia cell THP-1 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy GINS2 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy GINS2 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Retinoic-acid 31263158 Leukemia Homo sapiens synergy HIST1H2BK Downregulation Sci Rep Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 28404891 Leukemia Homo sapiens synergy HMGB1 Upregulation Oncotarget Acute promyelocytic leukemia cell NB4 ELISA Retinoic-acid 28404891 Leukemia Homo sapiens synergy HMGB1 Upregulation Oncotarget Acute promyelocytic leukemia cell HL-60 ELISA Retinoic-acid 28776567 Leukemia Homo sapiens synergy HO1 Upregulation Leukemia Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 25003661 Leukemia Homo sapiens synergy HO1 Upregulation Br J Cancer Acute promyelocytic leukemia cell HL-60 RT-PCR, Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy HO1 Upregulation Br J Cancer Acute monocytic leukemia cell THP-1 RT-PCR, Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy HO1 Upregulation Br J Cancer Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy HO1 Upregulation Br J Cancer Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 25855932 Leukemia Homo sapiens synergy HOXB8 Upregulation Eur Rev Med Pharmacol Sci Blood cell CD34+ progenitor QRT-PCR, Western blot Retinoic-acid 16107885 Leukemia Homo sapiens synergy HTERT Downregulation Leukemia Acute promyelocytic leukemia cell NB4 RT-PCR Retinoic-acid 18055984 Leukemia Homo sapiens synergy ICAM1 Upregulation Haematologica Acute promyelocytic leukemia cell NB4 IFA Retinoic-acid 28404891 Leukemia Homo sapiens synergy IL1B Upregulation Oncotarget Acute promyelocytic leukemia cell NB4 ELISA Retinoic-acid 28404891 Leukemia Homo sapiens synergy IL1B Upregulation Oncotarget Acute promyelocytic leukemia cell HL-60 ELISA Retinoic-acid 31078158 Leukemia Homo sapiens synergy IL6 Downregulation Cell Mol Biol (Noisy-le-grand) Acute promyelocytic leukemia cell NB4 Kit Retinoic-acid 28492552 Leukemia Homo sapiens synergy IRF8 Downregulation Cell Death Dis Acute promyelocytic leukemia progenitors cell C-kit+ apl progenitors RT-PCR Retinoic-acid 18055984 Leukemia Homo sapiens synergy ITGAM Downregulation Haematologica Acute promyelocytic leukemia cell NB4 IFA Retinoic-acid 28276286 Leukemia Homo sapiens synergy LDHA Downregulation Leuk Lymphoma Acute monocytic leukemia cell THP-1 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy LDHA Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy LDHA Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Retinoic-acid 20574048 Leukemia Homo sapiens synergy MAP1LC3A Upregulation Blood Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 20574048 Leukemia Homo sapiens synergy MAP1LC3A Upregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 28492552 Leukemia Homo sapiens synergy MEF2C Downregulation Cell Death Dis Acute promyelocytic leukemia progenitors cell C-kit+ apl progenitors RT-PCR Retinoic-acid 28492552 Leukemia Homo sapiens synergy MEIS1 Downregulation Cell Death Dis Acute promyelocytic leukemia progenitors cell C-kit+ apl progenitors RT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy MYC Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy MYC Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR, Western blot Retinoic-acid 17706770 Leukemia Homo sapiens synergy MYC Downregulation Leuk Res Acute promyelocytic leukemia cell HL-60 RT-PCR, Western blot Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy NESTIN Downregulation Tumour Biol Glioblastoma cell U-87 MG IFA Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy NESTIN Downregulation Tumour Biol Likely glioblastoma cell U-87 MG IFA Retinoic-acid 28276286 Leukemia Homo sapiens synergy NFE2L3 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy NFE2L3 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Retinoic-acid 11424005 Leukemia Homo sapiens synergy NFKBIA Upregulation Hematol J Lymphoma cell HuT 102 Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy NQO1 Upregulation Br J Cancer Acute promyelocytic leukemia cell HL-60 RT-PCR, Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy NQO1 Upregulation Br J Cancer Acute monocytic leukemia cell THP-1 RT-PCR, Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy NQO1 Upregulation Br J Cancer Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy NRF2 Upregulation Br J Cancer Acute promyelocytic leukemia cell HL-60 RT-PCR, Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy NRF2 Upregulation Br J Cancer Acute monocytic leukemia cell THP-1 RT-PCR, Western blot Retinoic-acid 25003661 Leukemia Homo sapiens synergy NRF2 Downregulation Br J Cancer Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 9596679 Leukemia Homo sapiens synergy P21 Upregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 9596679 Leukemia Homo sapiens synergy P21 Upregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 17706770 Leukemia Homo sapiens synergy P27 Upregulation Leuk Res Acute promyelocytic leukemia cell HL-60 Western blot Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy P53 Downregulation Tumour Biol Glioblastoma cell U-87 MG IFA Retinoic-acid 24399651 Brain-cancer Homo sapiens synergy P53 Upregulation Tumour Biol Likely glioblastoma cell U-87 MG IFA Retinoic-acid 28276286 Leukemia Homo sapiens synergy PARP Upregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy PARP Upregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 Western blot Retinoic-acid 11601217 Leukemia Homo sapiens synergy PARP1 Downregulation Zhonghua Xue Ye Xue Za Zhi Acute promyelocytic leukemia cell HL-60 Western blot Retinoic-acid 30093655 Breast-cancer Mus musculus synergy Pin1 Downregulation Nat Commun Embryonic fibroblast MEFs Western blot Retinoic-acid 30093655 Breast-cancer Homo sapiens synergy PIN1 Downregulation Nat Commun Breast cancer cell MDA-MB-231 Western blot Retinoic-acid 16408290 Leukemia Homo sapiens synergy PLCB2 Upregulation J Cell Biochem Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy PLK1 Downregulation Leuk Lymphoma Acute monocytic leukemia cell THP-1 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy PLK1 Downregulation Leuk Lymphoma Acute myeloid leukemia cell MOLM13 QRT-PCR Retinoic-acid 28276286 Leukemia Homo sapiens synergy PLK1 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Retinoic-acid 19029980 Leukemia Mus musculus synergy Pram1 Downregulation Nat Med - - Luciferase Retinoic-acid 9596679 Leukemia Homo sapiens synergy PRAM1 Downregulation Blood Acute promyelocytic leukemia cell NB4 IFA, Western blot Retinoic-acid 9596679 Leukemia Homo sapiens synergy PRAM1 Downregulation Blood Acute promyelocytic leukemia cell NB4 IFA, Western blot Retinoic-acid 20574048 Leukemia Homo sapiens synergy PRAM1 Downregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 31263158 Leukemia Homo sapiens synergy PRTN3 Upregulation Sci Rep Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 26892147 Leukemia Homo sapiens synergy PRTN3 Downregulation Life Sci Acute promyelocytic leukemia cell HL-60 QRT-PCR, Western blot Retinoic-acid 31263158 Leukemia Homo sapiens synergy RAB33A Upregulation Sci Rep Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 9596679 Leukemia Homo sapiens synergy RARa Downregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 9596679 Leukemia Homo sapiens synergy RARa Downregulation Blood Acute promyelocytic leukemia cell NB4 Western blot Retinoic-acid 31263158 Leukemia Homo sapiens synergy RARA Upregulation Sci Rep Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 31263158 Leukemia Homo sapiens synergy RARB Upregulation Sci Rep Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 26892147 Leukemia Homo sapiens synergy SP1 Upregulation Life Sci Acute promyelocytic leukemia cell HL-60 Western blot Retinoic-acid 28276286 Leukemia Homo sapiens synergy STAT5 Downregulation Leuk Lymphoma Biphenotypic B myelomonocytic leukemia cell MV-4-11 Western blot Retinoic-acid 16107885 Leukemia Homo sapiens synergy TA Downregulation Leukemia Acute promyelocytic leukemia cell NB4 ELISA Retinoic-acid 11424005 Leukemia Homo sapiens synergy TAX Downregulation Hematol J Lymphoma cell HuT 102 Western blot Retinoic-acid 11876987 Leukemia Homo sapiens synergy TF Upregulation Zhonghua Xue Ye Xue Za Zhi Histiocytic lymphoma cell U-937 RT-PCR Retinoic-acid 31263158 Leukemia Homo sapiens synergy TGM2 Upregulation Sci Rep Acute promyelocytic leukemia cell NB4 QRT-PCR Retinoic-acid 11798779 Leukemia Homo sapiens synergy TISSUE FACTOR Downregulation Zhonghua Yi Xue Za Zhi Acute promyelocytic leukemia cell NB4 RT-PCR Retinoic-acid 11798779 Leukemia Homo sapiens synergy TISSUE FACTOR Downregulation Zhonghua Yi Xue Za Zhi Acute promyelocytic leukemia cell APL RT-PCR Retinoic-acid 11779431 Leukemia Homo sapiens synergy TISSUE FACTOR Downregulation Chin Med J (Engl) Acute promyelocytic leukemia cell NB4 RT-PCR Retinoic-acid 28404891 Leukemia Homo sapiens synergy TNF Upregulation Oncotarget Acute promyelocytic leukemia cell NB4 ELISA Retinoic-acid 28404891 Leukemia Homo sapiens synergy TNF Upregulation Oncotarget Acute promyelocytic leukemia cell HL-60 ELISA Retinoic-acid 31078158 Leukemia Homo sapiens synergy TNF Downregulation Cell Mol Biol (Noisy-le-grand) Acute promyelocytic leukemia cell NB4 Kit Rhizoma-curcumae 17608231 Cataract Bos taurus synergy PCNA Downregulation Zhongguo Zhong Yao Za Zhi Lens epithelial cell LEC Flow cytometry RSK1 23377826 Leukemia Homo sapiens synergy RPS6KA1 Phosphorylation Cancer Biol Ther Histiocytic lymphoma cell U-937 Western blot RSK1 23377826 Leukemia Homo sapiens synergy RPS6KA1 Phosphorylation Cancer Biol Ther Acute myeloid leukemia cell MM6 Western blot RSK1 23377826 Leukemia Homo sapiens synergy RPS6KA1 Phosphorylation Cancer Biol Ther Acute promyelocytic leukemia cell NB4 Western blot Ruxolitinib 30012499 Leukemia Homo sapiens synergy - - Eur J Pharmacol Acute myelogenous leukemia cell KG-1 - Ruxolitinib 30012499 Leukemia Homo sapiens synergy - - Eur J Pharmacol Histiocytic lymphoma cell U-937 - Ruxolitinib 30012499 Leukemia Homo sapiens synergy CDK2 Downregulation Eur J Pharmacol Histiocytic lymphoma cell U-937 QRT-PCR Ruxolitinib 30012499 Leukemia Homo sapiens synergy H2AX Phosphorylation Eur J Pharmacol Histiocytic lymphoma cell U-937 Western blot Ruxolitinib 30012499 Leukemia Homo sapiens synergy PATM Upregulation Eur J Pharmacol Acute myelogenous leukemia cell KG-1 Western blot Ruxolitinib 30012499 Leukemia Homo sapiens synergy SURVIVIN Downregulation Eur J Pharmacol Histiocytic lymphoma cell U-937 QRT-PCR Rwj-241947 14977855 Prostate-cancer Homo sapiens synergy - - Clin Cancer Res Prostate carcinoma cell LNCaP - Rwj-241947 14977855 Prostate-cancer Homo sapiens synergy - - Clin Cancer Res Prostate carcinoma cell DU 145 - Rwj-241947 14977855 Breast-cancer Homo sapiens synergy - - Clin Cancer Res Breast cancer cell MCF7 - Rwj-241947 14977855 Myeloma Homo sapiens synergy - - Clin Cancer Res Myeloma cell NCI-H929 - Rwj-241947 14977855 Myeloma Homo sapiens synergy - - Clin Cancer Res Myeloma cell RPMI 8226 - Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Atp2a2 Downregulation Molecules Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Atp2a2 Downregulation Molecules - - Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Bad Upregulation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Bax Upregulation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Bcl2 Downregulation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Bclxll Downregulation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Casp12 Upregulation Molecules Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Casp12 Upregulation Molecules - - Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Casp3 Upregulation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Chop Upregulation Molecules Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Chop Upregulation Molecules - - Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Cytochrome c Upregulation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 29867492 Heart-toxicity Mus musculus detoxicity Drp1 Downregulation Front Pharmacol - - Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Erk1 Phosphorylation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Grp78 Upregulation Molecules Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Grp78 Upregulation Molecules - - Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Jnk Phosphorylation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Jnk Upregulation,Phosphorylation Molecules Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Jnk Upregulation,Phosphorylation Molecules - - Western blot Salvianolic-acid-a 29867492 Heart-toxicity Mus musculus detoxicity Mfn1 Upregulation Front Pharmacol - - Western blot Salvianolic-acid-a 29867492 Heart-toxicity Mus musculus detoxicity Mfn2 Upregulation Front Pharmacol - - Western blot Salvianolic-acid-a 29867492 Heart-toxicity Mus musculus detoxicity Opa1 Upregulation Front Pharmacol - - Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity P38 MAPK Phosphorylation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 28391263 Heart-toxicity Rattus norvegicus detoxicity Parp1 Upregulation Cell Physiol Biochem Heart myoblast H9C2 Western blot Salvianolic-acid-a 29867492 Heart-toxicity Mus musculus detoxicity Pgc1 Downregulation Front Pharmacol - - Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Plb Downregulation Molecules Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-a 30717322 Heart-toxicity Rattus norvegicus detoxicity Plb Downregulation Molecules - - Western blot Salvianolic-acid-b 23201927 Heart-toxicity Rattus norvegicus detoxicity - - Toxicol Lett Heart myoblast H9C2 - Salvianolic-acid-b 23662152 Liver-cancer Homo sapiens detoxicity - - Evid Based Complement Alternat Med Hepatocellular carcinoma cell HEPG2 - Salvianolic-acid-b 23662152 Cervical-cancer Homo sapiens detoxicity - - Evid Based Complement Alternat Med Cervical adenocarcinoma cell HeLa - Salvianolic-acid-b 23662152 Heart-toxicity Mus musculus detoxicity Akt1 Dephosphorylation Evid Based Complement Alternat Med - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Atf6 Upregulation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Atf6 Upregulation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Atp2a2 Downregulation Oncotarget - - Kit Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Atp2a2 Downregulation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Kit Salvianolic-acid-b 23201927 Heart-toxicity Rattus norvegicus detoxicity Bax Upregulation Toxicol Lett Heart myoblast H9C2 Western blot Salvianolic-acid-b 23662152 Heart-toxicity Mus musculus detoxicity Bax Upregulation Evid Based Complement Alternat Med - - Western blot Salvianolic-acid-b 23201927 Heart-toxicity Rattus norvegicus detoxicity Bcl2 Downregulation Toxicol Lett Heart myoblast H9C2 Western blot Salvianolic-acid-b 23662152 Heart-toxicity Mus musculus detoxicity Bcl2 Downregulation Evid Based Complement Alternat Med - - Western blot Salvianolic-acid-b 23201927 Heart-toxicity Rattus norvegicus detoxicity Bclxll Downregulation Toxicol Lett Heart myoblast H9C2 Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Camk2 Phosphorylation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Camk2 Phosphorylation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Casp12 Upregulation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Casp12 Upregulation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 23201927 Heart-toxicity Rattus norvegicus detoxicity Casp3 Upregulation Toxicol Lett Heart myoblast H9C2 Kit Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Chop Upregulation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Chop Upregulation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Eif2a Phosphorylation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Eif2a Phosphorylation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Erk1 Phosphorylation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Erk1 Phosphorylation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Grp78 Upregulation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Grp78 Upregulation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Ire1 Upregulation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Ire1 Upregulation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Ncx Upregulation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Ncx Upregulation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot Salvianolic-acid-b 29228618 Heart-toxicity Mus musculus detoxicity Plb Dephosphorylation Oncotarget - - Western blot Salvianolic-acid-b 29228618 Heart-toxicity Rattus norvegicus detoxicity Plb Dephosphorylation Oncotarget Ventricular cardiomyocyte Ventricular cardiomyocyte Western blot SB203580 18173754 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell MM.1S - SB203580 18173754 Myeloma Homo sapiens synergy - - Br J Haematol Multiple myeloma cell MM.1R - SB203580 18173754 Myeloma Homo sapiens synergy - - Br J Haematol Myeloma cell RPMI 8226 - SB203580 19846917 Lung-cancer Homo sapiens - GSH Upregulation Anticancer Res Lung cancer cell CALU-6 Kit SB203580 18173754 Myeloma Homo sapiens synergy HSP27 Phosphorylation Br J Haematol Myeloma cell RPMI 8226 Flow cytometry, Western blot SB203580 32683294 Lung-toxicity Homo sapiens detoxicity OCLN Downregulation Toxicol Lett Normal lung epithelial cell BEAS-2B QRT-PCR, Western blot SB203580 18173754 Myeloma Homo sapiens synergy P38 MAPK Phosphorylation Br J Haematol Myeloma cell RPMI 8226 Flow cytometry, Western blot Sec-o-glucosylhamaudol 27608960 Heart-toxicity Rattus norvegicus detoxicity HO1 Upregulation Toxicol In Vitro Heart myoblast H9C2 RT-PCR, Western blot Sec-o-glucosylhamaudol 27608960 Heart-toxicity Rattus norvegicus detoxicity Nqo1 Upregulation,Downregulation Toxicol In Vitro Heart myoblast H9C2 RT-PCR, Western blot Sec-o-glucosylhamaudol 27608960 Heart-toxicity Rattus norvegicus detoxicity Nrf2 Upregulation Toxicol In Vitro Heart myoblast H9C2 RT-PCR Selenium 23023949 Genotoxicity Poeciliopsis lucida detoxicity casp3 Upregulation Environ Toxicol Chem Hepatocellular carcinoma cell PLHC-1 Kit Shikonin 27655700 Liver-cancer Homo sapiens synergy - - Oncotarget Hepatocellular carcinoma cell HEPG2 - Shikonin 27655700 Liver-cancer Homo sapiens synergy - - Oncotarget Hepatocellular carcinoma cell HEP3B - Shikonin 27655700 Liver-cancer Homo sapiens synergy ATF4 Upregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Shikonin 27655700 Liver-cancer Homo sapiens synergy BAX Upregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Shikonin 27655700 Liver-cancer Homo sapiens synergy BCL2 Downregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Shikonin 27655700 Liver-cancer Homo sapiens synergy CASP3 Downregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Shikonin 27655700 Liver-cancer Homo sapiens synergy CASP3 Upregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Shikonin 27655700 Liver-cancer Homo sapiens synergy CHOP Upregulation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Shikonin 27655700 Liver-cancer Homo sapiens synergy EIF2A Phosphorylation Oncotarget Hepatocellular carcinoma cell HEPG2 Western blot Silibinin 28458011 Brain-cancer Homo sapiens synergy - - Food Chem Toxicol Glioblastoma cell A-172 - Silibinin 21969006 Brain-cancer Homo sapiens synergy MMP2 Upregulation Neurochem Res Glioblastoma cell U-87 MG QRT-PCR Silibinin 21969006 Brain-cancer Homo sapiens synergy MMP9 Downregulation Neurochem Res Glioblastoma cell U-87 MG QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy - - Asian Pac J Cancer Prev Histiocytic lymphoma cell U-937 - Sorafenib 31863650 Leukemia Homo sapiens synergy AKT1 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy AKT1 Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 30250637 Leukemia Homo sapiens synergy AKT1 Phosphorylation,Downregulation Oncotarget Acute myeloid leukemia cell MOLM14 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy AKT1 Phosphorylation,Downregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy AKT1 Downregulation Mol Cancer Ther Primary leukemia cell PRIMARY FLT3-ITD AML Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy AKT1 Dephosphorylation Tumour Biol Hepatocellular carcinoma cell HEPG2 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy AKT1 Dephosphorylation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy BAX Upregulation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy BCL-XL Downregulation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 31863650 Leukemia Homo sapiens synergy BCL2 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy BCL2 Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 25416439 Liver-cancer Homo sapiens synergy BCL2 Downregulation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy BCL2L11 Downregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 31863650 Leukemia Homo sapiens synergy BECN1 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy BECN1 Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy BRAF Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy BRAF Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 25416439 Liver-cancer Homo sapiens synergy CASP3 Downregulation Tumour Biol Hepatocellular carcinoma cell HEPG2 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy CASP3 Downregulation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy CCND1 Downregulation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy EIF4EBP1 Dephosphorylation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 18495609 Liver-cancer Homo sapiens synergy ERK1 Phosphorylation Nan Fang Yi Ke Da Xue Xue Bao Hepatocellular carcinoma cell HEPG2 Western blot Sorafenib 30250637 Leukemia Homo sapiens synergy ERK1 Phosphorylation,Downregulation Oncotarget Acute myeloid leukemia cell MOLM14 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy ERK1 Phosphorylation,Downregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 30250637 Leukemia Homo sapiens synergy FLT3 Phosphorylation,Downregulation Oncotarget Acute myeloid leukemia cell MOLM14 QRT-PCR, Western blot Sorafenib 30250637 Leukemia Homo sapiens synergy FLT3 Phosphorylation,Downregulation Oncotarget Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR, Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy FLT3 Phosphorylation,Downregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy FLT3 Phosphorylation,Downregulation Mol Cancer Ther Megakaryoblastic cell 32D Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy FLT3 Upregulation,Phosphorylation Mol Cancer Ther Megakaryoblastic cell 32D Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy FLT3 Downregulation Mol Cancer Ther Primary leukemia cell PRIMARY FLT3-ITD AML Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy GSK3B Upregulation,Phosphorylation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy GSK3B Dephosphorylation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy HDAC6 Downregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 30250637 Leukemia Homo sapiens synergy HOXA9 Downregulation Oncotarget Acute myeloid leukemia cell MOLM14 QRT-PCR Sorafenib 30250637 Leukemia Homo sapiens synergy HOXA9 Downregulation Oncotarget Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy JLK1 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy JLK1 Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy MAP1LC3A Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy MAP1LC3A Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 29959200 Leukemia Homo sapiens synergy MCL1 Downregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy MCL1 Downregulation Mol Cancer Ther Primary leukemia cell PRIMARY FLT3-ITD AML Western blot Sorafenib 30250637 Leukemia Homo sapiens synergy MEIS1 Downregulation Oncotarget Acute myeloid leukemia cell MOLM14 QRT-PCR Sorafenib 30250637 Leukemia Homo sapiens synergy MEIS1 Downregulation Oncotarget Biphenotypic B myelomonocytic leukemia cell MV-4-11 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy MEK1 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy MEK1 Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy MEK2 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy MEK2 Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 25416439 Liver-cancer Homo sapiens synergy MTOP Dephosphorylation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 31863650 Leukemia Homo sapiens synergy MTOR Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy MTOR Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 29959200 Leukemia Homo sapiens synergy PARP1 Upregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 31863650 Leukemia Homo sapiens synergy PI3K Downregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy PI3K Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy PTEN Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy PTEN Upregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy RAF1 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy RAF1 Upregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 29959200 Leukemia Homo sapiens synergy S6 Phosphorylation,Downregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 25416439 Liver-cancer Homo sapiens synergy S6K Dephosphorylation Tumour Biol Liver cancer cell Huh7 Western blot Sorafenib 30250637 Leukemia Homo sapiens synergy STAT5 Phosphorylation,Downregulation Oncotarget Acute myeloid leukemia cell MOLM14 Western blot Sorafenib 30127933 Liver-cancer Homo sapiens synergy TRAIL Upregulation Oncol Lett Liver cancer cell Huh7 Western blot Sorafenib 29959200 Leukemia Homo sapiens synergy TUBULIN Upregulation Mol Cancer Ther Acute myeloid leukemia cell MOLM13 Western blot Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFA Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFA Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFA Upregulation Asian Pac J Cancer Prev Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFA Downregulation Asian Pac J Cancer Prev Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFB Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFB Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFB Upregulation Asian Pac J Cancer Prev Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFB Downregulation Asian Pac J Cancer Prev Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFC Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFC Upregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFC Upregulation Asian Pac J Cancer Prev Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFR1 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFR1 Upregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFR1 Upregulation Asian Pac J Cancer Prev Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFR2 Upregulation Cell J Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 31863650 Leukemia Homo sapiens synergy VEGFR2 Downregulation Cell J Histiocytic lymphoma cell U-937 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFR2 Upregulation Asian Pac J Cancer Prev Acute myelogenous leukemia cell KG-1 QRT-PCR Sorafenib 28670885 Leukemia Homo sapiens synergy VEGFR2 Downregulation Asian Pac J Cancer Prev Histiocytic lymphoma cell U-937 QRT-PCR Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Akt1 Dephosphorylation Biomed Pharmacother Heart myoblast H9C2 Western blot Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Bax Upregulation Biomed Pharmacother Heart myoblast H9C2 Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Bcl2 Downregulation Biomed Pharmacother Heart myoblast H9C2 Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Mus musculus detoxicity Casp3 Upregulation Biomed Pharmacother - - Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Casp3 Upregulation Biomed Pharmacother Heart myoblast H9C2 Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Casp8 Upregulation Biomed Pharmacother Heart myoblast H9C2 Western blot Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Casp9 Upregulation Biomed Pharmacother Heart myoblast H9C2 Western blot Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Mus musculus detoxicity Cat Downregulation Biomed Pharmacother - - Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Cat Downregulation Biomed Pharmacother Heart myoblast H9C2 Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Mus musculus detoxicity Gpx1 Downregulation Biomed Pharmacother - - Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Gpx1 Downregulation Biomed Pharmacother Heart myoblast H9C2 Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity HO1 Downregulation Biomed Pharmacother Heart myoblast H9C2 Western blot Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Ldh Upregulation Biomed Pharmacother Heart myoblast H9C2 Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Nrf2 Downregulation Biomed Pharmacother Heart myoblast H9C2 Western blot Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Ros1 Upregulation Biomed Pharmacother Heart myoblast H9C2 Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Mus musculus detoxicity Sod Downregulation Biomed Pharmacother - - Kit Sorbus-pohuashanensis-(hante)-hedl-flavonoids 28092839 Heart-toxicity Rattus norvegicus detoxicity Sod Downregulation Biomed Pharmacother Heart myoblast H9C2 Kit SP600125 20074581 Skin-toxicity Homo sapiens synergy - - Toxicol Appl Pharmacol Keratinocyte HACAT - SP600125 16972261 Leukemia Homo sapiens synergy - - J Cell Physiol Acute promyelocytic leukemia cell NB4 - SP600125 16972261 Leukemia Homo sapiens synergy BAX Upregulation J Cell Physiol Histiocytic lymphoma cell U-937 Western blot SP600125 16972261 Leukemia Homo sapiens synergy BCL2 Upregulation J Cell Physiol Histiocytic lymphoma cell U-937 Western blot SP600125 16972261 Leukemia Homo sapiens synergy CASP8 Upregulation J Cell Physiol Histiocytic lymphoma cell U-937 Western blot SP600125 16972261 Leukemia Homo sapiens synergy Cytochrome c Upregulation J Cell Physiol Histiocytic lymphoma cell U-937 Western blot SP600125 19846917 Lung-cancer Homo sapiens - GSH Upregulation Anticancer Res Lung cancer cell CALU-6 Kit SP600125 16972261 Leukemia Homo sapiens synergy P38 MAPK Phosphorylation J Cell Physiol Histiocytic lymphoma cell U-937 Western blot STI-571 18024285 Leukemia Homo sapiens synergy - - Nan Fang Yi Ke Da Xue Xue Bao Leukemia cell BCR/ABL+-CD34+ - STI-571 11368438 Leukemia Homo sapiens synergy ABL1 Downregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy ABL1 Downregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy AKT1 Downregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy AKT1 Downregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy BCL2L1 Upregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy CASP3 Downregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy CASP9 Downregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy CASP9 Downregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy Cytochrome c Upregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy Cytochrome c Upregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy GATA1 Downregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy GATA1 Downregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy GSK3A Dephosphorylation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy GSK3A Dephosphorylation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy P30 Upregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy P30 Upregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy PARP Upregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy PARP Upregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot STI-571 11368438 Leukemia Homo sapiens synergy XIAP Upregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy XIAP Downregulation Leukemia Acute promyelocytic leukemia cell HL-60 Western blot STI-571 11368438 Leukemia Homo sapiens synergy XIAP Downregulation Leukemia Chronic myelogenous leukemia cell K-562 Western blot Sulforaphane 22922937 Myeloma Homo sapiens synergy - - Oncol Rep Multiple myeloma cell PCNY-1 - Sulforaphane 22922937 Myeloma Homo sapiens synergy - - Oncol Rep Multiple myeloma cell MM1.S - Sulforaphane 22922937 Myeloma Homo sapiens synergy - - Oncol Rep Multiple myeloma cell MM1.R - Sulforaphane 22922937 Myeloma Homo sapiens synergy - - Oncol Rep Multiple myeloma cell KMS-11 - Sulforaphane 22922937 Myeloma Homo sapiens synergy CASP3 Upregulation Oncol Rep Multiple myeloma cell KMS-11 Western blot Sulforaphane 22922937 Myeloma Homo sapiens synergy HSP90 Upregulation Oncol Rep Multiple myeloma cell KMS-11 Western blot Sulforaphane 22922937 Myeloma Homo sapiens synergy PARP1 Upregulation Oncol Rep Multiple myeloma cell KMS-11 Western blot Sulforaphane 22922937 Myeloma Homo sapiens synergy XBP1 Upregulation Oncol Rep Multiple myeloma cell KMS-11 RT-PCR Sulforaphane 22922937 Myeloma Homo sapiens synergy XBP1 Upregulation Oncol Rep Myeloma cell ARP-1 RT-PCR Sulindac 21515355 Leukemia Homo sapiens synergy - - Toxicol In Vitro Leukemia cell Jurkat - Sulindac 21515355 Leukemia Homo sapiens synergy - - Toxicol In Vitro Chronic myelogenous leukemia cell K-562 - Sulindac 21515355 Leukemia Homo sapiens synergy - - Toxicol In Vitro Acute promyelocytic leukemia cell HL-60 - Sulindac 21515355 Leukemia Homo sapiens synergy - - Toxicol In Vitro Leukemia cell HPB-ALL - Sulindac 18281123 Lung-cancer Homo sapiens synergy - - Lung Cancer Lung cancer cell NCI-H1299 - Sulindac 16950207 Lung-cancer Homo sapiens synergy - - Biochem Pharmacol Lung adenocarcinoma cell A549 - Sulindac 16685442 Lung-cancer Homo sapiens synergy - - Int J Oncol Lung cancer cell NCI-H157 - Sulindac 16685442 Lung-cancer Homo sapiens synergy BAX Downregulation Int J Oncol Lung cancer cell NCI-H157 Western blot Sulindac 16685442 Lung-cancer Homo sapiens synergy BCL-XL Downregulation Int J Oncol Lung cancer cell NCI-H157 Western blot Sulindac 16950207 Lung-cancer Homo sapiens synergy Cytochrome c Upregulation Biochem Pharmacol Lung adenocarcinoma cell A549 Western blot Sulindac 18636201 Lung-cancer Homo sapiens synergy ERK1 Phosphorylation Oncol Rep Lung cancer cell NCI-H157 Western blot Sulindac 18636201 Lung-cancer Homo sapiens synergy HO1 Upregulation Oncol Rep Lung cancer cell NCI-H157 Western blot Sulindac 18575716 Colorectal-cancer Homo sapiens synergy IKAPPAB Dephosphorylation Oncol Rep Colorectal carcinoma cell HCT116 Western blot Sulindac 18636201 Lung-cancer Homo sapiens synergy JNK Phosphorylation Oncol Rep Lung cancer cell NCI-H157 Western blot Sulindac 18281123 Lung-cancer Homo sapiens synergy JNK Phosphorylation Lung Cancer Lung cancer cell NCI-H1299 Western blot Sulindac 18575716 Colorectal-cancer Homo sapiens synergy NFKB Upregulation Oncol Rep Colorectal carcinoma cell HCT116 Western blot Sulindac 18636201 Lung-cancer Homo sapiens synergy P38 MAPK Phosphorylation Oncol Rep Lung cancer cell NCI-H157 Western blot Sulindac 18636201 Lung-cancer Homo sapiens synergy ROS1 Upregulation Oncol Rep Lung cancer cell NCI-H157 Flow cytometry Sulindac 18281123 Lung-cancer Homo sapiens synergy ROS1 Upregulation Lung Cancer Lung cancer cell NCI-H1299 Kit Sulindac 16950207 Lung-cancer Homo sapiens synergy SURVIVIN Downregulation Biochem Pharmacol Lung adenocarcinoma cell A549 RT-PCR, Western blot Sulindac-sulfide 15354410 Lung-cancer Homo sapiens synergy - - J Exp Clin Cancer Res Lung adenocarcinoma cell A549 - Tamoxifen 21687957 Breast-cancer Homo sapiens synergy - - Oncol Rep Breast cancer cell MCF7 - Tamoxifen 21687957 Breast-cancer Homo sapiens synergy DNMT1 Downregulation Oncol Rep Ductal carcinoma cell MDA-MB-435S Western blot Tamoxifen 21687957 Breast-cancer Homo sapiens synergy ESRA Downregulation Oncol Rep Ductal carcinoma cell MDA-MB-435S IHC, Western blot Tannic-acid 18790533 Leukemia Homo sapiens synergy - - Leuk Res Acute promyelocytic leukemia cell HL-60 - Tannic-acid 18790533 Leukemia Homo sapiens synergy - - Leuk Res Peripheral blood mononuclear cell PBMC - Tanshinone-ii-a 20369471 Leukemia Homo sapiens synergy BCL2 Downregulation Sichuan Da Xue Xue Bao Yi Xue Ban Acute promyelocytic leukemia cell NB4 Flow cytometry Tanshinone-ii-a 20369471 Leukemia Homo sapiens synergy P53 Upregulation Sichuan Da Xue Xue Bao Yi Xue Ban Acute promyelocytic leukemia cell NB4 Flow cytometry Tanshinone-ii-a 19950589 Leukemia Homo sapiens synergy PGP Downregulation Sichuan Da Xue Xue Bao Yi Xue Ban Acute promyelocytic leukemia cell MR-2 IHC Taurine 31468423 Liver-toxicity Mus musculus detoxicity - - Adv Exp Med Biol - - - Taurine 20804627 Neuronal-toxicity Mus musculus detoxicity 8-nitroguanine Upregulation J Biomed Sci - - IHC Taurine 28849511 Kidney-toxicity Mus musculus detoxicity 8-OHdG Upregulation Adv Exp Med Biol - - IHC Taurine 30677399 Liver-toxicity Homo sapiens detoxicity ACTA2 Upregulation Chem Biol Interact Hepatic stellate cell LX-2 Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Akt1 Downregulation Int J Biochem Cell Biol - - Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Akt1 Downregulation Int J Biochem Cell Biol Myoblast cell C2C12 Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity Bax Upregulation Biomed Pharmacother - - Western blot Taurine 30237538 Liver-toxicity Homo sapiens detoxicity CASP1 Upregulation Cell Death Dis Hepatocellular carcinoma cell HEPG2 Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Cd36 Upregulation Int J Biochem Cell Biol - - Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Cd36 Upregulation Int J Biochem Cell Biol Myoblast cell C2C12 Western blot Taurine 30677399 Liver-toxicity Homo sapiens detoxicity COL1A1 Upregulation Chem Biol Interact Hepatic stellate cell LX-2 Western blot Taurine 30237538 Liver-toxicity Homo sapiens detoxicity CTSB Upregulation Cell Death Dis Hepatocellular carcinoma cell HEPG2 Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Glut4 Downregulation Int J Biochem Cell Biol - - Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Glut4 Downregulation Int J Biochem Cell Biol Myoblast cell C2C12 Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Gsk Upregulation Int J Biochem Cell Biol - - Western blot Taurine 30237538 Liver-toxicity Homo sapiens detoxicity IL1B Upregulation Cell Death Dis Hepatocellular carcinoma cell HEPG2 Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Irs Downregulation Int J Biochem Cell Biol - - Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Irs Downregulation Int J Biochem Cell Biol Myoblast cell C2C12 Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Map1lc3a Upregulation Int J Biochem Cell Biol - - Western blot Taurine 28849506 Neuronal-toxicity Mus musculus detoxicity Map1lc3a Upregulation Adv Exp Med Biol - - Western blot Taurine 27291853 Liver-toxicity Rattus norvegicus detoxicity Map1lc3a Upregulation Sci Rep - - Western blot Taurine 26775255 Pancreas-toxicity Rattus norvegicus detoxicity Map1lc3a Upregulation Biochimie - - Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity Map1lc3a Downregulation Biomed Pharmacother - - Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity Map1lc3a Downregulation Biomed Pharmacother Insulin-secreting cell INS-1 Western blot Taurine 27291853 Liver-toxicity Homo sapiens detoxicity MAP1LC3A Upregulation Sci Rep Hepatocellular carcinoma cell HEPG2 Western blot Taurine 30677399 Liver-toxicity Homo sapiens detoxicity MAP1LC3A Upregulation Chem Biol Interact Hepatic stellate cell LX-2 Western blot Taurine 30237538 Liver-toxicity Homo sapiens detoxicity MAP1LC3A Upregulation Cell Death Dis Hepatocellular carcinoma cell HEPG2 Western blot Taurine 28849506 Neuronal-toxicity Mus musculus detoxicity Mda Upregulation Adv Exp Med Biol - - Kit Taurine 30237538 Liver-toxicity Homo sapiens detoxicity NLRP3 Upregulation Cell Death Dis Hepatocellular carcinoma cell HEPG2 Western blot Taurine 28849506 Neuronal-toxicity Mus musculus detoxicity NRF2 Downregulation Adv Exp Med Biol - - Western blot Taurine 27291853 Liver-toxicity Rattus norvegicus detoxicity NRF2 Downregulation Sci Rep - - Western blot Taurine 27291853 Liver-toxicity Homo sapiens detoxicity NRF2 Downregulation Sci Rep Hepatocellular carcinoma cell HEPG2 Western blot Taurine 26775255 Pancreas-toxicity Rattus norvegicus detoxicity NRF2 Downregulation Biochimie - - Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity p62 Upregulation Int J Biochem Cell Biol - - Western blot Taurine 28849506 Neuronal-toxicity Mus musculus detoxicity P62 Downregulation Adv Exp Med Biol - - Western blot Taurine 27291853 Liver-toxicity Rattus norvegicus detoxicity P62 Downregulation Sci Rep - - Western blot Taurine 27291853 Liver-toxicity Homo sapiens detoxicity P62 Downregulation Sci Rep Hepatocellular carcinoma cell HEPG2 Western blot Taurine 30677399 Liver-toxicity Homo sapiens detoxicity P62 Downregulation Chem Biol Interact Hepatic stellate cell LX-2 Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity P62 Upregulation Biomed Pharmacother - - Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity P62 Upregulation Biomed Pharmacother Insulin-secreting cell INS-1 Western blot Taurine 30237538 Liver-toxicity Homo sapiens detoxicity P62 Upregulation Cell Death Dis Hepatocellular carcinoma cell HEPG2 Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity Park Downregulation Biomed Pharmacother - - Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity Park Downregulation Biomed Pharmacother Insulin-secreting cell INS-1 Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity Pink1 Downregulation Biomed Pharmacother - - Western blot Taurine 30677399 Liver-toxicity Homo sapiens detoxicity PPARA Upregulation Chem Biol Interact Hepatic stellate cell LX-2 Western blot Taurine 27291853 Liver-toxicity Rattus norvegicus detoxicity Pparg Downregulation Sci Rep - - RT-PCR, Western blot Taurine 30551535 Pancreas-toxicity Rattus norvegicus detoxicity Pparg Downregulation Biomed Pharmacother Insulin-secreting cell INS-1 Western blot Taurine 27291853 Liver-toxicity Homo sapiens detoxicity PPARG Downregulation Sci Rep Hepatocellular carcinoma cell HEPG2 Western blot Taurine 31059810 Muscle-toxicity Mus musculus detoxicity Ros1 Upregulation Int J Biochem Cell Biol Myoblast cell C2C12 Kit Taurine 28849461 Neuronal-toxicity Mus musculus detoxicity Trbeta1 Downregulation Adv Exp Med Biol - - QRT-PCR, Western blot Taurine 26775255 Pancreas-toxicity Rattus norvegicus detoxicity Trx Downregulation Biochimie - - QRT-PCR Taurine 27291853 Liver-toxicity Rattus norvegicus detoxicity Trx Downregulation Sci Rep - - Western blot Taurine 27291853 Liver-toxicity Homo sapiens detoxicity TRX Downregulation Sci Rep Hepatocellular carcinoma cell HEPG2 Western blot temozolomide 31002372 Brain-cancer Homo sapiens synergy - - Oncol Rep Glioblastoma of unknown origin cell GUO - temozolomide 31002372 Brain-cancer Homo sapiens synergy - - Oncol Rep Glioblastoma cell U-138-MG - temozolomide 31002372 Brain-cancer Homo sapiens synergy - - Oncol Rep Glioma cell U251MG - Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy BAX Upregulation PLoS One Acute promyelocytic leukemia cell NB4 RT-PCR, Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy BAX Upregulation PLoS One Primary acute promyelocytic leukemia cell Primary APL cell RT-PCR, Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy BCL2 Downregulation PLoS One Acute promyelocytic leukemia cell NB4 RT-PCR, Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy BCL2 Downregulation PLoS One Primary acute promyelocytic leukemia cell Primary APL cell RT-PCR, Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy CASP12 Upregulation PLoS One Acute promyelocytic leukemia cell NB4 Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy HMOX1 Upregulation PLoS One Acute promyelocytic leukemia cell NB4 RT-PCR Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy HMOX1 Upregulation PLoS One Primary acute promyelocytic leukemia cell Primary APL cell RT-PCR Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy NFKB Downregulation PLoS One Acute promyelocytic leukemia cell NB4 RT-PCR, Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy P53 Upregulation PLoS One Acute promyelocytic leukemia cell NB4 Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy PML Downregulation PLoS One Acute promyelocytic leukemia cell NB4 Western blot Tetraarsenictetrasulfide 26110921 Leukemia Homo sapiens synergy PML Downregulation PLoS One Primary acute promyelocytic leukemia cell Primary APL cell Western blot Tetradecanoylphorbol-acetate 24985180 Leukemia Homo sapiens synergy P38 MAPK Phosphorylation Zhonghua Xue Ye Xue Za Zhi Acute myeloid leukemia cell Kasumi-1 Western blot Tetramethylpyrazine 22331136 Leukemia Homo sapiens synergy - - Braz J Med Biol Res Acute promyelocytic leukemia cell HL-60 - Tetramethylpyrazine 22331136 Leukemia Homo sapiens synergy CDK2 Downregulation Braz J Med Biol Res Acute promyelocytic leukemia cell HL-60 Western blot Tetramethylpyrazine 22331136 Leukemia Homo sapiens synergy CYCE Downregulation Braz J Med Biol Res Acute promyelocytic leukemia cell HL-60 Western blot Tetramethylpyrazine 22331136 Leukemia Homo sapiens synergy ITGAM Upregulation Braz J Med Biol Res Acute promyelocytic leukemia cell HL-60 Kit Tetrandrine 24548979 Lung-cancer Homo sapiens synergy - - Int J Clin Pharmacol Ther Lung adenocarcinoma cell A549 - Tetrandrine 24548979 Liver-cancer Homo sapiens synergy - - Int J Clin Pharmacol Ther Hepatocellular carcinoma cell HEPG2 - Tetrandrine 24548979 Cervical-cancer Homo sapiens synergy - - Int J Clin Pharmacol Ther Cervical adenocarcinoma cell HeLa - Thalidomide 31721534 Leukemia Homo sapiens synergy - - Cell J Acute myelogenous leukemia cell KG-1 - Thalidomide 31721534 Leukemia Homo sapiens synergy - - Cell J Histiocytic lymphoma cell U-937 - Thalidomide 22966360 Leukemia Homo sapiens synergy - - 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Gsh Upregulation J Environ Pathol Toxicol Oncol - - Kit Vitamin-C 19888912 Heart-toxicity Cavia porcellus detoxicity Ldh Upregulation J Environ Pathol Toxicol Oncol - - Kit Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Il1b Downregulation PPAR Res - - ELISA Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Il6 Downregulation PPAR Res - - ELISA Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Il8 Downregulation PPAR Res - - ELISA Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Map1lc3a Upregulation PPAR Res - - QRT-PCR,Western blot Vitamin-D 31205465 Rheumatoid-arthritis Homo sapiens synergy MAP1LC3A Upregulation PPAR Res Fibroblast-like synoviocyte fibroblast-like synoviocytes QRT-PCR,Western blot Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Mmp13 Downregulation PPAR Res - - ELISA Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Mmp3 Downregulation PPAR Res - - ELISA Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Mtor Downregulation,Dephosphorylation PPAR Res - - QRT-PCR,Western blot Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy p62 Downregulation PPAR Res - - QRT-PCR,Western blot Vitamin-D 31205465 Rheumatoid-arthritis Mus musculus synergy Pparg Upregulation PPAR Res - - QRT-PCR,Western blot Vitamin-D 31205465 Rheumatoid-arthritis Homo sapiens synergy PPARG Upregulation PPAR Res Fibroblast-like synoviocyte fibroblast-like synoviocytes QRT-PCR,Western blot Vitamin-D 31205465 Rheumatoid-arthritis Homo sapiens synergy VDR Upregulation PPAR Res Fibroblast-like synoviocyte fibroblast-like synoviocytes QRT-PCR,Western blot Vitamin-D3 24661615 Leukemia Homo sapiens synergy - - Exp Hematol Oncol Acute promyelocytic leukemia cell HL-60 - Vitamin-D3 23660868 Leukemia Homo sapiens synergy BAX Upregulation Oncol Rep Acute promyelocytic leukemia cell HL-60 RT-PCR, Western blot Vitamin-D3 23660868 Leukemia Homo sapiens synergy BAX Upregulation Oncol Rep Chronic myelogenous leukemia cell K-562 RT-PCR, Western blot Vitamin-D3 23660868 Leukemia Homo sapiens synergy BCL2 Downregulation Oncol Rep Acute promyelocytic leukemia cell HL-60 RT-PCR, Western blot Vitamin-D3 23660868 Leukemia Homo sapiens synergy BCL2 Downregulation Oncol Rep Chronic myelogenous leukemia cell K-562 RT-PCR, Western blot Vitamin-D3 23660868 Leukemia Homo sapiens synergy CASP3 Upregulation Oncol Rep Acute promyelocytic leukemia cell HL-60 RT-PCR, Western blot Vitamin-D3 23660868 Leukemia Homo sapiens synergy CASP3 Upregulation Oncol Rep Chronic myelogenous leukemia cell K-562 RT-PCR, Western blot Vitamin-E 27464034 Hematologic-toxicity Rattus norvegicus detoxicity - - J Basic Clin Physiol Pharmacol - - - Vitamin-E 27464034 Liver-toxicity Rattus norvegicus detoxicity - - J Basic Clin Physiol Pharmacol - - - Vitamin-E 15272721 Liver-toxicity Mus musculus detoxicity - - J Environ Sci (China) - - - Vitamin-E 15272721 Kidney-toxicity Mus musculus detoxicity - - J Environ Sci (China) - - - Vitamin-K2 24273890 Leukemia Homo sapiens synergy ERK1 Downregulation,Dephosphorylation Pharmazie Acute promyelocytic leukemia cell HL-60 Western blot Vitamin-K2 24273890 Leukemia Homo sapiens synergy JNK Upregulation,Phosphorylation Pharmazie Acute promyelocytic leukemia cell HL-60 Western blot Vitamin-K2 24273890 Leukemia Homo sapiens synergy P38 MAPK Phosphorylation Pharmazie Acute promyelocytic leukemia cell HL-60 Western blot Vorinostat 27189198 Leukemia Homo sapiens synergy - - J Int Med Res Acute promyelocytic leukemia cell NB4 - Vorinostat 26038719 Leukemia Homo sapiens synergy - - PeerJ Chronic myelogenous leukemia cell K-562 - Vorinostat 27189198 Leukemia Homo sapiens synergy AKT1 Downregulation,Dephosphorylation J Int Med Res Acute promyelocytic leukemia cell NB4 Western blot Vorinostat 26038719 Leukemia Homo sapiens synergy AKT1 Downregulation,Dephosphorylation PeerJ Chronic myelogenous leukemia cell K-562 Western blot Vorinostat 27189198 Leukemia Homo sapiens synergy BCL2 Downregulation J Int Med Res Acute promyelocytic leukemia cell NB4 Western blot Vorinostat 27189198 Leukemia Homo sapiens synergy H4 Downregulation J Int Med Res Acute promyelocytic leukemia cell NB4 Western blot Vorinostat 27189198 Leukemia Homo sapiens synergy Pram1 Downregulation J Int Med Res Acute promyelocytic leukemia cell NB4 Western blot Vorinostat 26038719 Leukemia Homo sapiens synergy SIGLEC1 Downregulation PeerJ Chronic myelogenous leukemia cell K-562 Western blot Vs-5584 29574283 Leukemia Homo sapiens synergy - - Biomed Pharmacother Acute lymphoblastic leukemia cell NALM6 - Vs-5584 29574283 Leukemia Homo sapiens synergy BIM Upregulation Biomed Pharmacother Acute lymphoblastic leukemia cell NALM6 QRT-PCR Vs-5584 29574283 Leukemia Homo sapiens synergy FASL Upregulation Biomed Pharmacother Acute lymphoblastic leukemia cell NALM6 QRT-PCR Vs-5584 29574283 Leukemia Homo sapiens synergy IKAPPAB Dephosphorylation Biomed Pharmacother Acute lymphoblastic leukemia cell NALM6 Western blot Vs-5584 29574283 Leukemia Homo sapiens synergy MYC Downregulation Biomed Pharmacother Acute lymphoblastic leukemia cell NALM6 QRT-PCR Wortmannin 18937079 Liver-cancer Homo sapiens synergy - - Med Oncol Hepatocellular carcinoma cell SMMC-7721 - Wortmannin 18937079 Liver-cancer Homo sapiens synergy - - Med Oncol Hepatocellular carcinoma cell HEP3B - Wortmannin 18937079 Liver-cancer Homo sapiens synergy AKT1 Dephosphorylation Med Oncol Hepatocellular carcinoma cell HEPG2 Western blot Wortmannin 18937079 Liver-cancer Homo sapiens synergy ERK1 Dephosphorylation,Upregulation Med Oncol Hepatocellular carcinoma cell HEPG2 Western blot Wortmannin 18937079 Liver-cancer Homo sapiens synergy FOXO3A Dephosphorylation,Upregulation Med Oncol Hepatocellular carcinoma cell HEPG2 Western blot Wortmannin 18937079 Liver-cancer Homo sapiens synergy JNK Upregulation,Phosphorylation Med Oncol Hepatocellular carcinoma cell HEPG2 Western blot Wortmannin 18937079 Liver-cancer Homo sapiens synergy P27 Upregulation Med Oncol Hepatocellular carcinoma cell HEPG2 Western blot Wortmannin 18937079 Liver-cancer Homo sapiens synergy P38 MAPK Phosphorylation Med Oncol Hepatocellular carcinoma cell HEPG2 Western blot Y27632 32954055 Vascular-toxicity Rattus norvegicus detoxicity SM22ALPHA Downregulation Bioact Mater smooth muscle cell A7r5 Western blot Y27632 32954055 Vascular-toxicity Rattus norvegicus detoxicity Yap Phosphorylation Bioact Mater smooth muscle cell A7r5 Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity akt1 Downregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity bax Upregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity bcl2 Downregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity casp3 Downregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity casp9 Downregulation Environ Pollut - - Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity CLDN11 Downregulation Fish Shellfish Immunol - - QRT-PCR Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity CLDN15 Downregulation Fish Shellfish Immunol - - QRT-PCR Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity CLDN3 Downregulation Fish Shellfish Immunol - - QRT-PCR,Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity CLDN4 Downregulation Fish Shellfish Immunol - - QRT-PCR Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity cldn7 Downregulation Fish Shellfish Immunol - - QRT-PCR Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity erk1 Upregulation Environ Pollut - - Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity ikba Downregulation Fish Shellfish Immunol - - Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity il1b Upregulation Fish Shellfish Immunol - - QRT-PCR Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity il6 Upregulation Fish Shellfish Immunol - - QRT-PCR Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity il8 Upregulation Fish Shellfish Immunol - - QRT-PCR Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity jnk Upregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity map1lc3a Upregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity mtor Downregulation Environ Pollut - - Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity nfkb Upregulation Fish Shellfish Immunol - - Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity ocln Upregulation Fish Shellfish Immunol - - QRT-PCR,Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity p38 mapk Upregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity p62 Downregulation Environ Pollut - - Western blot Zinc 31344536 Heart-toxicity Cyprinus carpio detoxicity pi3k Downregulation Environ Pollut - - Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity ZO1 Downregulation Fish Shellfish Immunol - - QRT-PCR,Western blot Zinc 31585240 Gastrointestinal-toxicity Cyprinus carpio detoxicity ZO2 Downregulation Fish Shellfish Immunol - - QRT-PCR Zvad-fmk 22391177 Myeloma Homo sapiens synergy - - Zhongguo Shi Yan Xue Ye Xue Za Zhi Myeloma cell RPMI 8226 -